Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and p...

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Autores principales:	Simon N. Willis, Julie Tellier, Yang Liao, Stephanie Trezise, Amanda Light, Kristy O’Donnell, Lee Ann Garrett-Sinha, Wei Shi, David M. Tarlinton, Stephen L. Nutt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37dfa3d4d0b943728cbf40939c1d7a57
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spelling	oai:doaj.org-article:37dfa3d4d0b943728cbf40939c1d7a572021-12-02T14:42:07ZEnvironmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB10.1038/s41467-017-01605-12041-1723https://doaj.org/article/37dfa3d4d0b943728cbf40939c1d7a572017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01605-1https://doaj.org/toc/2041-1723Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and plasma cell differentiation.Simon N. WillisJulie TellierYang LiaoStephanie TreziseAmanda LightKristy O’DonnellLee Ann Garrett-SinhaWei ShiDavid M. TarlintonStephen L. NuttNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon N. Willis Julie Tellier Yang Liao Stephanie Trezise Amanda Light Kristy O’Donnell Lee Ann Garrett-Sinha Wei Shi David M. Tarlinton Stephen L. Nutt Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
description	Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and plasma cell differentiation.
format	article
author	Simon N. Willis Julie Tellier Yang Liao Stephanie Trezise Amanda Light Kristy O’Donnell Lee Ann Garrett-Sinha Wei Shi David M. Tarlinton Stephen L. Nutt
author_facet	Simon N. Willis Julie Tellier Yang Liao Stephanie Trezise Amanda Light Kristy O’Donnell Lee Ann Garrett-Sinha Wei Shi David M. Tarlinton Stephen L. Nutt
author_sort	Simon N. Willis
title	Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
title_short	Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
title_full	Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
title_fullStr	Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
title_full_unstemmed	Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
title_sort	environmental sensing by mature b cells is controlled by the transcription factors pu.1 and spib
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37dfa3d4d0b943728cbf40939c1d7a57
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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

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