Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress

Radiation therapy is a common treatment for head and neck cancers. However, because of the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary glands (SGs), mucous membranes, and swallowing muscles in the head and neck regions, radiotherapy inevitably causes damage...

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Autores principales:	Zijing Liu, Lihua Dong, Zhuangzhuang Zheng, Shiyu Liu, Shouliang Gong, Lingbin Meng, Ying Xin, Xin Jiang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	head and neck cancer radiotherapy salivary glands injury oxidative stress Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/37e118a47b664d3dbaf656d882156543
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spelling	oai:doaj.org-article:37e118a47b664d3dbaf656d8821565432021-11-25T16:25:42ZMechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress10.3390/antiox101116662076-3921https://doaj.org/article/37e118a47b664d3dbaf656d8821565432021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1666https://doaj.org/toc/2076-3921Radiation therapy is a common treatment for head and neck cancers. However, because of the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary glands (SGs), mucous membranes, and swallowing muscles in the head and neck regions, radiotherapy inevitably causes damage to these normal tissues. Among them, SG injury is a serious adverse event, and its clinical manifestations include changes in taste, difficulty chewing and swallowing, oral infections, and dental caries. These clinical symptoms seriously reduce a patient’s quality of life. Therefore, it is important to clarify the mechanism of SG injury caused by radiotherapy. Although the mechanism of radiation-induced SG injury has not yet been determined, recent studies have shown that the mechanisms of calcium signaling, microvascular injury, cellular senescence, and apoptosis are closely related to oxidative stress. In this article, we review the mechanism by which radiotherapy causes oxidative stress and damages the SGs. In addition, we discuss effective methods to prevent and treat radiation-induced SG damage.Zijing LiuLihua DongZhuangzhuang ZhengShiyu LiuShouliang GongLingbin MengYing XinXin JiangMDPI AGarticlehead and neck cancerradiotherapysalivary glandsinjuryoxidative stressTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1666, p 1666 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck cancer radiotherapy salivary glands injury oxidative stress Therapeutics. Pharmacology RM1-950
spellingShingle	head and neck cancer radiotherapy salivary glands injury oxidative stress Therapeutics. Pharmacology RM1-950 Zijing Liu Lihua Dong Zhuangzhuang Zheng Shiyu Liu Shouliang Gong Lingbin Meng Ying Xin Xin Jiang Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress
description	Radiation therapy is a common treatment for head and neck cancers. However, because of the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary glands (SGs), mucous membranes, and swallowing muscles in the head and neck regions, radiotherapy inevitably causes damage to these normal tissues. Among them, SG injury is a serious adverse event, and its clinical manifestations include changes in taste, difficulty chewing and swallowing, oral infections, and dental caries. These clinical symptoms seriously reduce a patient’s quality of life. Therefore, it is important to clarify the mechanism of SG injury caused by radiotherapy. Although the mechanism of radiation-induced SG injury has not yet been determined, recent studies have shown that the mechanisms of calcium signaling, microvascular injury, cellular senescence, and apoptosis are closely related to oxidative stress. In this article, we review the mechanism by which radiotherapy causes oxidative stress and damages the SGs. In addition, we discuss effective methods to prevent and treat radiation-induced SG damage.
format	article
author	Zijing Liu Lihua Dong Zhuangzhuang Zheng Shiyu Liu Shouliang Gong Lingbin Meng Ying Xin Xin Jiang
author_facet	Zijing Liu Lihua Dong Zhuangzhuang Zheng Shiyu Liu Shouliang Gong Lingbin Meng Ying Xin Xin Jiang
author_sort	Zijing Liu
title	Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress
title_short	Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress
title_full	Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress
title_fullStr	Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress
title_full_unstemmed	Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress
title_sort	mechanism, prevention, and treatment of radiation-induced salivary gland injury related to oxidative stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/37e118a47b664d3dbaf656d882156543
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Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress

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