Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease.

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Autores principales:	Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37e17f6f0f9040dab7fdc72ee507d46c
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spelling	oai:doaj.org-article:37e17f6f0f9040dab7fdc72ee507d46c2021-12-02T14:42:00ZPyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model10.1038/ncomms155922041-1723https://doaj.org/article/37e17f6f0f9040dab7fdc72ee507d46c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15592https://doaj.org/toc/2041-1723Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease.Albert GiraltVeronica BritoQuentin ChevyClémence SimonnetYo OtsuCarmen Cifuentes-DíazBenoit de PinsRenata CouraJordi AlberchSílvia GinésJean-Christophe PoncerJean-Antoine GiraultNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Albert Giralt Veronica Brito Quentin Chevy Clémence Simonnet Yo Otsu Carmen Cifuentes-Díaz Benoit de Pins Renata Coura Jordi Alberch Sílvia Ginés Jean-Christophe Poncer Jean-Antoine Girault Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
description	Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease.
format	article
author	Albert Giralt Veronica Brito Quentin Chevy Clémence Simonnet Yo Otsu Carmen Cifuentes-Díaz Benoit de Pins Renata Coura Jordi Alberch Sílvia Ginés Jean-Christophe Poncer Jean-Antoine Girault
author_facet	Albert Giralt Veronica Brito Quentin Chevy Clémence Simonnet Yo Otsu Carmen Cifuentes-Díaz Benoit de Pins Renata Coura Jordi Alberch Sílvia Ginés Jean-Christophe Poncer Jean-Antoine Girault
author_sort	Albert Giralt
title	Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
title_short	Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
title_full	Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
title_fullStr	Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
title_full_unstemmed	Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
title_sort	pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a huntington’s disease model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37e17f6f0f9040dab7fdc72ee507d46c
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Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

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