Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease.

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Detalles Bibliográficos
Autores principales: Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/37e17f6f0f9040dab7fdc72ee507d46c
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