2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications

Abstract A novel turn-on two-photon fluorescent probe NS-N 2 H 4 was developed with the 2-benzothiazoleacetonitrile as a new recognition site for the detection of hydrazine (N2H4). The two-photon probe exhibited favorable properties including high selectivity, low cytotoxicity and almost 16-fold flu...

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Autores principales:	Jian-Yong Wang, Zhan-Rong Liu, Mingguang Ren, Weiying Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37e19de6a6374aa5aedc4c5312c035ab
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spelling	oai:doaj.org-article:37e19de6a6374aa5aedc4c5312c035ab2021-12-02T11:41:20Z2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications10.1038/s41598-017-01656-w2045-2322https://doaj.org/article/37e19de6a6374aa5aedc4c5312c035ab2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01656-whttps://doaj.org/toc/2045-2322Abstract A novel turn-on two-photon fluorescent probe NS-N 2 H 4 was developed with the 2-benzothiazoleacetonitrile as a new recognition site for the detection of hydrazine (N2H4). The two-photon probe exhibited favorable properties including high selectivity, low cytotoxicity and almost 16-fold fluorescence enhancement in the presence of N2H4 in solution. The probe could be used to image hydrazine in the living cells. Notably, we also used the two-photon fluorescent probe to image hydrazine in the tissue imaging for the first time. Furthermore, by the way of probe-loaded TLC plate, we further monitored vapor of hydrazine. Therefore, the novel two-photon probe is expected to be employed to detect N2H4 in biosamples and environmental pollution and the new recognition site will be widely applied to construct fluorescent probes for the detection of N2H4.Jian-Yong WangZhan-Rong LiuMingguang RenWeiying LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Yong Wang Zhan-Rong Liu Mingguang Ren Weiying Lin 2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
description	Abstract A novel turn-on two-photon fluorescent probe NS-N 2 H 4 was developed with the 2-benzothiazoleacetonitrile as a new recognition site for the detection of hydrazine (N2H4). The two-photon probe exhibited favorable properties including high selectivity, low cytotoxicity and almost 16-fold fluorescence enhancement in the presence of N2H4 in solution. The probe could be used to image hydrazine in the living cells. Notably, we also used the two-photon fluorescent probe to image hydrazine in the tissue imaging for the first time. Furthermore, by the way of probe-loaded TLC plate, we further monitored vapor of hydrazine. Therefore, the novel two-photon probe is expected to be employed to detect N2H4 in biosamples and environmental pollution and the new recognition site will be widely applied to construct fluorescent probes for the detection of N2H4.
format	article
author	Jian-Yong Wang Zhan-Rong Liu Mingguang Ren Weiying Lin
author_facet	Jian-Yong Wang Zhan-Rong Liu Mingguang Ren Weiying Lin
author_sort	Jian-Yong Wang
title	2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
title_short	2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
title_full	2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
title_fullStr	2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
title_full_unstemmed	2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
title_sort	2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37e19de6a6374aa5aedc4c5312c035ab
work_keys_str_mv	AT jianyongwang 2benzothiazoleacetonitrilebasedtwophotonfluorescentprobeforhydrazineanditsbioimagingandenvironmentalapplications AT zhanrongliu 2benzothiazoleacetonitrilebasedtwophotonfluorescentprobeforhydrazineanditsbioimagingandenvironmentalapplications AT mingguangren 2benzothiazoleacetonitrilebasedtwophotonfluorescentprobeforhydrazineanditsbioimagingandenvironmentalapplications AT weiyinglin 2benzothiazoleacetonitrilebasedtwophotonfluorescentprobeforhydrazineanditsbioimagingandenvironmentalapplications
_version_	1718395392582746112

2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications

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