Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna

Abstract As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming su...

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Autores principales:	Mikael T. Ekvall, Jonas Hedberg, Inger Odnevall Wallinder, Anders Malmendal, Lars-Anders Hansson, Tommy Cedervall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37e8e254ab314a62b3f5ca6473f01c0f
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spelling	oai:doaj.org-article:37e8e254ab314a62b3f5ca6473f01c0f2021-12-02T14:49:18ZAdsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna10.1038/s41598-021-90053-52045-2322https://doaj.org/article/37e8e254ab314a62b3f5ca6473f01c0f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90053-5https://doaj.org/toc/2045-2322Abstract As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC–Co) and cobalt (Co) on the crustacean Daphnia magna is postponed in the presence of natural biological degradation products (eco-corona biomolecules). For Daphnia exposed to WC–Co NPs the survival time increased with 20–25% and for Co NPs with 30–47% after mixing the particles with a solution of eco-corona biomolecules before exposure. This suggests that an eco-corona, composed of biomolecules always present in natural ecosystems, reduces the toxic potency of both studied NPs. Further, the eco-coronas did not affect the particle uptake, suggesting that the reduction in toxicity was related to the particle-organism interaction after eco-corona formation. In a broader context, this implies that although the increasing use and production of NPs may constitute a novel, global environmental threat, the acute toxicity and long-term effects of some NPs will, at least under certain conditions, be reduced as they enter natural ecosystems.Mikael T. EkvallJonas HedbergInger Odnevall WallinderAnders MalmendalLars-Anders HanssonTommy CedervallNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mikael T. Ekvall Jonas Hedberg Inger Odnevall Wallinder Anders Malmendal Lars-Anders Hansson Tommy Cedervall Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna
description	Abstract As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC–Co) and cobalt (Co) on the crustacean Daphnia magna is postponed in the presence of natural biological degradation products (eco-corona biomolecules). For Daphnia exposed to WC–Co NPs the survival time increased with 20–25% and for Co NPs with 30–47% after mixing the particles with a solution of eco-corona biomolecules before exposure. This suggests that an eco-corona, composed of biomolecules always present in natural ecosystems, reduces the toxic potency of both studied NPs. Further, the eco-coronas did not affect the particle uptake, suggesting that the reduction in toxicity was related to the particle-organism interaction after eco-corona formation. In a broader context, this implies that although the increasing use and production of NPs may constitute a novel, global environmental threat, the acute toxicity and long-term effects of some NPs will, at least under certain conditions, be reduced as they enter natural ecosystems.
format	article
author	Mikael T. Ekvall Jonas Hedberg Inger Odnevall Wallinder Anders Malmendal Lars-Anders Hansson Tommy Cedervall
author_facet	Mikael T. Ekvall Jonas Hedberg Inger Odnevall Wallinder Anders Malmendal Lars-Anders Hansson Tommy Cedervall
author_sort	Mikael T. Ekvall
title	Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna
title_short	Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna
title_full	Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna
title_fullStr	Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna
title_full_unstemmed	Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna
title_sort	adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in daphnia magna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37e8e254ab314a62b3f5ca6473f01c0f
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Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna

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