Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence

Abstract We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The traject...

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Autores principales:	Eun Jeong Choi, Hye Ah Lee, Bomi Park, Bohyun Park, Hae Soon Kim, Young Sun Hong, Hyesook Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37eccbb682c34f9ba9559b4c67e3b676
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spelling	oai:doaj.org-article:37eccbb682c34f9ba9559b4c67e3b6762021-11-21T12:18:38ZTrajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence10.1038/s41598-021-01566-y2045-2322https://doaj.org/article/37eccbb682c34f9ba9559b4c67e3b6762021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01566-yhttps://doaj.org/toc/2045-2322Abstract We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The trajectory of cMetS in childhood (from 3 to 12 years of age) was identified in 833 children who participated in the Ewha Birth and Growth Study. The associations between cMetS and hs-CRP and CIMT were analyzed in 204 out of 833 children who participated in the follow-up at 13–15 years of age and measured hs-CRP and CIMT. Among the 833 children, three groups were classified: cMetS maintained at a low level (n = 198, 23.77%), middle level (n = 530, 63.63%), and at high levels (n = 105, 12.61%). The group with a stable-high cMetS trajectory showed significantly higher hs-CRP levels, and the statistical significance was maintained after adjusting for covariates. This study found that a consistently high cMetS in childhood was significantly associated with higher hs-CRP levels in adolescents, suggesting that it is necessary to intervene in metabolic risk factors early in life to reduce the risk of cardiovascular disease later in life.Eun Jeong ChoiHye Ah LeeBomi ParkBohyun ParkHae Soon KimYoung Sun HongHyesook ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Jeong Choi Hye Ah Lee Bomi Park Bohyun Park Hae Soon Kim Young Sun Hong Hyesook Park Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
description	Abstract We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The trajectory of cMetS in childhood (from 3 to 12 years of age) was identified in 833 children who participated in the Ewha Birth and Growth Study. The associations between cMetS and hs-CRP and CIMT were analyzed in 204 out of 833 children who participated in the follow-up at 13–15 years of age and measured hs-CRP and CIMT. Among the 833 children, three groups were classified: cMetS maintained at a low level (n = 198, 23.77%), middle level (n = 530, 63.63%), and at high levels (n = 105, 12.61%). The group with a stable-high cMetS trajectory showed significantly higher hs-CRP levels, and the statistical significance was maintained after adjusting for covariates. This study found that a consistently high cMetS in childhood was significantly associated with higher hs-CRP levels in adolescents, suggesting that it is necessary to intervene in metabolic risk factors early in life to reduce the risk of cardiovascular disease later in life.
format	article
author	Eun Jeong Choi Hye Ah Lee Bomi Park Bohyun Park Hae Soon Kim Young Sun Hong Hyesook Park
author_facet	Eun Jeong Choi Hye Ah Lee Bomi Park Bohyun Park Hae Soon Kim Young Sun Hong Hyesook Park
author_sort	Eun Jeong Choi
title	Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
title_short	Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
title_full	Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
title_fullStr	Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
title_full_unstemmed	Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
title_sort	trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37eccbb682c34f9ba9559b4c67e3b676
work_keys_str_mv	AT eunjeongchoi trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence AT hyeahlee trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence AT bomipark trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence AT bohyunpark trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence AT haesoonkim trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence AT youngsunhong trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence AT hyesookpark trajectorypatternsforcontinuousmetabolicsyndromescoreinchildhoodandthecardiovascularriskinadolescence
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Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence

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