Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats

Ai Takemura,1 Tatsuro Egawa,2 Takuji Tanaka,3 Takashi Kuramoto,4 Tatsuya Hayashi,2 Akihiko Ishihara1 1Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan; 2Laboratory of Sports and Exercise Medicine, Graduate School...

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Autores principales:	Takemura A, Egawa T, Tanaka T, Kuramoto T, Hayashi T, Ishihara A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	colonic inflammation dextran sulfate sodium Kyoto Apc Delta rats mild hyperbaric oxygen oxidative metabolism Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/37ee48f109ba48cb8f70ce9928824d91
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spelling	oai:doaj.org-article:37ee48f109ba48cb8f70ce9928824d912021-12-02T04:44:52ZEffects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats1178-7031https://doaj.org/article/37ee48f109ba48cb8f70ce9928824d912019-10-01T00:00:00Zhttps://www.dovepress.com/effects-of-exposure-to-mild-hyperbaric-oxygen-on-dss-induced-colonic-i-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Ai Takemura,1 Tatsuro Egawa,2 Takuji Tanaka,3 Takashi Kuramoto,4 Tatsuya Hayashi,2 Akihiko Ishihara1 1Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan; 2Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan; 3Department of Diagnostic Pathology, Gifu Municipal Hospital, Gifu 500-8513, Japan; 4Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, Atsugi 243-0034, JapanCorrespondence: Ai TakemuraDepartment of Sports Research, Japan Institute of Sport Sciences, Tokyo 115-0056, JapanTel +81-75-753-2996Fax +81-75-753-6771Email takemura.ai.46c@kyoto-u.jpPurpose: In rodents, dextran sulfate sodium (DSS)-induced diarrhea and colonic inflammation have similar symptoms to those of ulcerative colitis in humans. We examined the effects of exposure to mild hyperbaric oxygen (MHO) at an atmospheric pressure of 1317 hPa with 40% oxygen on DSS-induced diarrhea and colonic inflammation in rats.Methods: Five-week-old male Kyoto Apc Delta (KAD) rats (n = 12) were administered 2% DSS through drinking water for 1 week. Subsequently, DSS-treated male rats were not subjected to any further treatment (n = 6) or exposed to MHO (n = 6) for 2 weeks. Age-matched KAD rats not subjected to DSS treatment or exposed to MHO were used as the control group (n = 6).Results: Control rats did not exhibit diarrhea and colonic inflammation. However, DSS-treated rats exhibited diarrhea and colonic inflammation, regardless of exposure to MHO. Exposure to MHO for 2 weeks led to decreased incidence of diarrhea in DSS-treated rats (p < 0.05). Exposure to MHO had no effect on colonic inflammation in DSS-treated rats (p = 0.12).Conclusion: Exposure to MHO for 2 weeks can improve diarrhea but cannot attenuate colonic inflammation, possibly due to the short exposure duration (2 weeks) used in this study.Keywords: colonic inflammation, dextran sulfate sodium, Kyoto Apc Delta rats, mild hyperbaric oxygen, oxidative metabolismTakemura AEgawa TTanaka TKuramoto THayashi TIshihara ADove Medical Pressarticlecolonic inflammationdextran sulfate sodiumKyoto Apc Delta ratsmild hyperbaric oxygenoxidative metabolismPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 12, Pp 293-299 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	colonic inflammation dextran sulfate sodium Kyoto Apc Delta rats mild hyperbaric oxygen oxidative metabolism Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	colonic inflammation dextran sulfate sodium Kyoto Apc Delta rats mild hyperbaric oxygen oxidative metabolism Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Takemura A Egawa T Tanaka T Kuramoto T Hayashi T Ishihara A Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats
description	Ai Takemura,1 Tatsuro Egawa,2 Takuji Tanaka,3 Takashi Kuramoto,4 Tatsuya Hayashi,2 Akihiko Ishihara1 1Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan; 2Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan; 3Department of Diagnostic Pathology, Gifu Municipal Hospital, Gifu 500-8513, Japan; 4Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, Atsugi 243-0034, JapanCorrespondence: Ai TakemuraDepartment of Sports Research, Japan Institute of Sport Sciences, Tokyo 115-0056, JapanTel +81-75-753-2996Fax +81-75-753-6771Email takemura.ai.46c@kyoto-u.jpPurpose: In rodents, dextran sulfate sodium (DSS)-induced diarrhea and colonic inflammation have similar symptoms to those of ulcerative colitis in humans. We examined the effects of exposure to mild hyperbaric oxygen (MHO) at an atmospheric pressure of 1317 hPa with 40% oxygen on DSS-induced diarrhea and colonic inflammation in rats.Methods: Five-week-old male Kyoto Apc Delta (KAD) rats (n = 12) were administered 2% DSS through drinking water for 1 week. Subsequently, DSS-treated male rats were not subjected to any further treatment (n = 6) or exposed to MHO (n = 6) for 2 weeks. Age-matched KAD rats not subjected to DSS treatment or exposed to MHO were used as the control group (n = 6).Results: Control rats did not exhibit diarrhea and colonic inflammation. However, DSS-treated rats exhibited diarrhea and colonic inflammation, regardless of exposure to MHO. Exposure to MHO for 2 weeks led to decreased incidence of diarrhea in DSS-treated rats (p < 0.05). Exposure to MHO had no effect on colonic inflammation in DSS-treated rats (p = 0.12).Conclusion: Exposure to MHO for 2 weeks can improve diarrhea but cannot attenuate colonic inflammation, possibly due to the short exposure duration (2 weeks) used in this study.Keywords: colonic inflammation, dextran sulfate sodium, Kyoto Apc Delta rats, mild hyperbaric oxygen, oxidative metabolism
format	article
author	Takemura A Egawa T Tanaka T Kuramoto T Hayashi T Ishihara A
author_facet	Takemura A Egawa T Tanaka T Kuramoto T Hayashi T Ishihara A
author_sort	Takemura A
title	Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats
title_short	Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats
title_full	Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats
title_fullStr	Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats
title_full_unstemmed	Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats
title_sort	effects of exposure to mild hyperbaric oxygen on dss-induced colonic inflammation and diarrhea in rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/37ee48f109ba48cb8f70ce9928824d91
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Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats

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