Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Measuring precise protein turnover rates in animals is technically challenging at the proteomic level. Here, Fornasiero and colleagues use isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brain
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/37f09442e22e41daa48bdc27c646c649 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:37f09442e22e41daa48bdc27c646c649 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:37f09442e22e41daa48bdc27c646c6492021-12-02T16:49:19ZPrecisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions10.1038/s41467-018-06519-02041-1723https://doaj.org/article/37f09442e22e41daa48bdc27c646c6492018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06519-0https://doaj.org/toc/2041-1723Measuring precise protein turnover rates in animals is technically challenging at the proteomic level. Here, Fornasiero and colleagues use isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brainEugenio F. FornasieroSunit MandadHanna WildhagenMihai AlevraBurkhard RammnerSarva KeihaniFelipe OpazoInga UrbanTill IschebeckM. Sadman SakibMaryam K. FardKoray KirliTonatiuh Pena CentenoRamon O. VidalRaza-Ur RahmanEva BenitoAndré FischerSven DennerleinPeter RehlingIvo FeussnerStefan BonnMikael SimonsHenning UrlaubSilvio O. RizzoliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Eugenio F. Fornasiero Sunit Mandad Hanna Wildhagen Mihai Alevra Burkhard Rammner Sarva Keihani Felipe Opazo Inga Urban Till Ischebeck M. Sadman Sakib Maryam K. Fard Koray Kirli Tonatiuh Pena Centeno Ramon O. Vidal Raza-Ur Rahman Eva Benito André Fischer Sven Dennerlein Peter Rehling Ivo Feussner Stefan Bonn Mikael Simons Henning Urlaub Silvio O. Rizzoli Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| description |
Measuring precise protein turnover rates in animals is technically challenging at the proteomic level. Here, Fornasiero and colleagues use isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brain |
| format |
article |
| author |
Eugenio F. Fornasiero Sunit Mandad Hanna Wildhagen Mihai Alevra Burkhard Rammner Sarva Keihani Felipe Opazo Inga Urban Till Ischebeck M. Sadman Sakib Maryam K. Fard Koray Kirli Tonatiuh Pena Centeno Ramon O. Vidal Raza-Ur Rahman Eva Benito André Fischer Sven Dennerlein Peter Rehling Ivo Feussner Stefan Bonn Mikael Simons Henning Urlaub Silvio O. Rizzoli |
| author_facet |
Eugenio F. Fornasiero Sunit Mandad Hanna Wildhagen Mihai Alevra Burkhard Rammner Sarva Keihani Felipe Opazo Inga Urban Till Ischebeck M. Sadman Sakib Maryam K. Fard Koray Kirli Tonatiuh Pena Centeno Ramon O. Vidal Raza-Ur Rahman Eva Benito André Fischer Sven Dennerlein Peter Rehling Ivo Feussner Stefan Bonn Mikael Simons Henning Urlaub Silvio O. Rizzoli |
| author_sort |
Eugenio F. Fornasiero |
| title |
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| title_short |
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| title_full |
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| title_fullStr |
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| title_full_unstemmed |
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| title_sort |
precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/37f09442e22e41daa48bdc27c646c649 |
| work_keys_str_mv |
AT eugenioffornasiero preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT sunitmandad preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT hannawildhagen preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT mihaialevra preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT burkhardrammner preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT sarvakeihani preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT felipeopazo preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT ingaurban preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT tillischebeck preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT msadmansakib preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT maryamkfard preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT koraykirli preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT tonatiuhpenacenteno preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT ramonovidal preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT razaurrahman preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT evabenito preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT andrefischer preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT svendennerlein preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT peterrehling preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT ivofeussner preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT stefanbonn preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT mikaelsimons preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT henningurlaub preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions AT silvioorizzoli preciselymeasuredproteinlifetimesinthemousebrainrevealdifferencesacrosstissuesandsubcellularfractions |
| _version_ |
1718383327932579840 |