Replication fork reversal triggers fork degradation in BRCA2-defective cells

BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replication forks from degradation. Here the authors reveal how HR factors cooperate in fork remodeling, showing that BRCA2 supports RAD51 loading on the regressed arms of reversed replication forks to protect them...

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Autores principales:	Sofija Mijic, Ralph Zellweger, Nagaraja Chappidi, Matteo Berti, Kurt Jacobs, Karun Mutreja, Sebastian Ursich, Arnab Ray Chaudhuri, Andre Nussenzweig, Pavel Janscak, Massimo Lopes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37f10f169bf74902a273599741eefa33
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spelling	oai:doaj.org-article:37f10f169bf74902a273599741eefa332021-12-02T15:37:02ZReplication fork reversal triggers fork degradation in BRCA2-defective cells10.1038/s41467-017-01164-52041-1723https://doaj.org/article/37f10f169bf74902a273599741eefa332017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01164-5https://doaj.org/toc/2041-1723BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replication forks from degradation. Here the authors reveal how HR factors cooperate in fork remodeling, showing that BRCA2 supports RAD51 loading on the regressed arms of reversed replication forks to protect them from degradation.Sofija MijicRalph ZellwegerNagaraja ChappidiMatteo BertiKurt JacobsKarun MutrejaSebastian UrsichArnab Ray ChaudhuriAndre NussenzweigPavel JanscakMassimo LopesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sofija Mijic Ralph Zellweger Nagaraja Chappidi Matteo Berti Kurt Jacobs Karun Mutreja Sebastian Ursich Arnab Ray Chaudhuri Andre Nussenzweig Pavel Janscak Massimo Lopes Replication fork reversal triggers fork degradation in BRCA2-defective cells
description	BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replication forks from degradation. Here the authors reveal how HR factors cooperate in fork remodeling, showing that BRCA2 supports RAD51 loading on the regressed arms of reversed replication forks to protect them from degradation.
format	article
author	Sofija Mijic Ralph Zellweger Nagaraja Chappidi Matteo Berti Kurt Jacobs Karun Mutreja Sebastian Ursich Arnab Ray Chaudhuri Andre Nussenzweig Pavel Janscak Massimo Lopes
author_facet	Sofija Mijic Ralph Zellweger Nagaraja Chappidi Matteo Berti Kurt Jacobs Karun Mutreja Sebastian Ursich Arnab Ray Chaudhuri Andre Nussenzweig Pavel Janscak Massimo Lopes
author_sort	Sofija Mijic
title	Replication fork reversal triggers fork degradation in BRCA2-defective cells
title_short	Replication fork reversal triggers fork degradation in BRCA2-defective cells
title_full	Replication fork reversal triggers fork degradation in BRCA2-defective cells
title_fullStr	Replication fork reversal triggers fork degradation in BRCA2-defective cells
title_full_unstemmed	Replication fork reversal triggers fork degradation in BRCA2-defective cells
title_sort	replication fork reversal triggers fork degradation in brca2-defective cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37f10f169bf74902a273599741eefa33
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Replication fork reversal triggers fork degradation in BRCA2-defective cells

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