Replication fork reversal triggers fork degradation in BRCA2-defective cells

Replication fork reversal triggers fork degradation in BRCA2-defective cells

BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replication forks from degradation. Here the authors reveal how HR factors cooperate in fork remodeling, showing that BRCA2 supports RAD51 loading on the regressed arms of reversed replication forks to protect them...

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Autores principales: Sofija Mijic, Ralph Zellweger, Nagaraja Chappidi, Matteo Berti, Kurt Jacobs, Karun Mutreja, Sebastian Ursich, Arnab Ray Chaudhuri, Andre Nussenzweig, Pavel Janscak, Massimo Lopes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/37f10f169bf74902a273599741eefa33
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