The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa

Background: With the roll-out of antiretroviral treatment (ART), the life expectancy of people with HIV and, hence, morbidity from non-communicable diseases, including pulmonary diseases, have increased. Objectives: This research study aims to investigate whether HIV infection and ART use are assoc...

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Autores principales:	Oda E. van den Berg, Erica J. Shaddock, Sarah L. Stacey, Charles Feldman, Roos E. Barth, Diederick E. Grobbee, Willem D.F. Venter, Kerstin Klipstein-Grobusch, Alinda G. Vos
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2021
Materias:	hiv antiretroviral therapy tuberculosis spirometry sub-saharan africa obstructive lung disorder copd asthma pulmonary function Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/37f1f01db3fc4e7db1a914d8d3c53e01
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spelling	oai:doaj.org-article:37f1f01db3fc4e7db1a914d8d3c53e012021-11-24T07:47:23ZThe influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa1608-96932078-675110.4102/sajhivmed.v22i1.1312https://doaj.org/article/37f1f01db3fc4e7db1a914d8d3c53e012021-11-01T00:00:00Zhttps://sajhivmed.org.za/index.php/hivmed/article/view/1312https://doaj.org/toc/1608-9693https://doaj.org/toc/2078-6751Background: With the roll-out of antiretroviral treatment (ART), the life expectancy of people with HIV and, hence, morbidity from non-communicable diseases, including pulmonary diseases, have increased. Objectives: This research study aims to investigate whether HIV infection and ART use are associated with pulmonary function, given the high frequency of pulmonary infections, including tuberculosis (TB), associated with HIV. Method: Adults living with HIV (ART-naïve, on first- or second-line ART), and age and sex matched HIV-negative controls were included in a cross-sectional study in Johannesburg, South Africa. Spirometry was performed to determine lung function, measuring the forced expiratory volume in one second (FEV1), the forced vital capacity (FVC) and the FEV1/FVC ratio before (pre), and after (post), short-acting bronchodilator. The association of HIV infection and ART use with pulmonary function was analysed using linear regression models, adjusting for age, gender, body surface area (BSA), employment, education, smoking and TB. Results: Overall, 548 participants (62% women) were included with a mean age of 38 (standard deviation [s.d.] 9.5) years. No effect of HIV or ART on post-FEV1 was observed in adjusted analysis. Additional adjustment for TB resulted in a higher post-FEV1 in participants on ART compared with HIV-negative participants, whereas TB was associated with a lower FEV1. No effect of HIV and ART on post-FEV1/FVC was observed. Conclusion: HIV infection and ART use were not associated with reduced pulmonary function in this urban African population. Tuberculosis showed a mediating effect on the association between HIV, ART and pulmonary function.Oda E. van den BergErica J. ShaddockSarah L. StaceyCharles FeldmanRoos E. BarthDiederick E. GrobbeeWillem D.F. VenterKerstin Klipstein-GrobuschAlinda G. VosAOSISarticlehivantiretroviral therapytuberculosisspirometrysub-saharan africaobstructive lung disordercopdasthmapulmonary functionPublic aspects of medicineRA1-1270ENSouthern African Journal of HIV Medicine, Vol 22, Iss 1, Pp e1-e8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv antiretroviral therapy tuberculosis spirometry sub-saharan africa obstructive lung disorder copd asthma pulmonary function Public aspects of medicine RA1-1270
spellingShingle	hiv antiretroviral therapy tuberculosis spirometry sub-saharan africa obstructive lung disorder copd asthma pulmonary function Public aspects of medicine RA1-1270 Oda E. van den Berg Erica J. Shaddock Sarah L. Stacey Charles Feldman Roos E. Barth Diederick E. Grobbee Willem D.F. Venter Kerstin Klipstein-Grobusch Alinda G. Vos The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
description	Background: With the roll-out of antiretroviral treatment (ART), the life expectancy of people with HIV and, hence, morbidity from non-communicable diseases, including pulmonary diseases, have increased. Objectives: This research study aims to investigate whether HIV infection and ART use are associated with pulmonary function, given the high frequency of pulmonary infections, including tuberculosis (TB), associated with HIV. Method: Adults living with HIV (ART-naïve, on first- or second-line ART), and age and sex matched HIV-negative controls were included in a cross-sectional study in Johannesburg, South Africa. Spirometry was performed to determine lung function, measuring the forced expiratory volume in one second (FEV1), the forced vital capacity (FVC) and the FEV1/FVC ratio before (pre), and after (post), short-acting bronchodilator. The association of HIV infection and ART use with pulmonary function was analysed using linear regression models, adjusting for age, gender, body surface area (BSA), employment, education, smoking and TB. Results: Overall, 548 participants (62% women) were included with a mean age of 38 (standard deviation [s.d.] 9.5) years. No effect of HIV or ART on post-FEV1 was observed in adjusted analysis. Additional adjustment for TB resulted in a higher post-FEV1 in participants on ART compared with HIV-negative participants, whereas TB was associated with a lower FEV1. No effect of HIV and ART on post-FEV1/FVC was observed. Conclusion: HIV infection and ART use were not associated with reduced pulmonary function in this urban African population. Tuberculosis showed a mediating effect on the association between HIV, ART and pulmonary function.
format	article
author	Oda E. van den Berg Erica J. Shaddock Sarah L. Stacey Charles Feldman Roos E. Barth Diederick E. Grobbee Willem D.F. Venter Kerstin Klipstein-Grobusch Alinda G. Vos
author_facet	Oda E. van den Berg Erica J. Shaddock Sarah L. Stacey Charles Feldman Roos E. Barth Diederick E. Grobbee Willem D.F. Venter Kerstin Klipstein-Grobusch Alinda G. Vos
author_sort	Oda E. van den Berg
title	The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
title_short	The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
title_full	The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
title_fullStr	The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
title_full_unstemmed	The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
title_sort	influence of hiv infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-saharan africa
publisher	AOSIS
publishDate	2021
url	https://doaj.org/article/37f1f01db3fc4e7db1a914d8d3c53e01
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The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa

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