Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes
Stepwise acquisition of mutations gives rise to myelodysplastic syndrome (MDS) in older adults. Here, the authors infer the clonal hierarchy of 1809 MDS patients, revealing insights into the evolution of dominant/secondary mutations and how these impact clinical phenotypes like leukemic progression...
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Nature Portfolio
2019
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oai:doaj.org-article:37f1f1df587f487aa52451ea6ac3c3462021-12-02T14:38:38ZInvariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes10.1038/s41467-019-13001-y2041-1723https://doaj.org/article/37f1f1df587f487aa52451ea6ac3c3462019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13001-yhttps://doaj.org/toc/2041-1723Stepwise acquisition of mutations gives rise to myelodysplastic syndrome (MDS) in older adults. Here, the authors infer the clonal hierarchy of 1809 MDS patients, revealing insights into the evolution of dominant/secondary mutations and how these impact clinical phenotypes like leukemic progression and therapy response.Yasunobu NagataHideki MakishimaCassandra M. KerrBartlomiej P. PrzychodzenMai AlyAbhinav GoyalHassan AwadaMohammad Fahad AsadTeodora KuzmanovicHiromichi SuzukiTetsuichi YoshizatoKenichi YoshidaKenichi ChibaHiroko TanakaYuichi ShiraishiSatoru MiyanoSudipto MukherjeeThomas LaFramboiseAziz NazhaMikkael A. SekeresTomas RadivoyevitchTorsten HaferlachSeishi OgawaJaroslaw P. MaciejewskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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Science Q |
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Science Q Yasunobu Nagata Hideki Makishima Cassandra M. Kerr Bartlomiej P. Przychodzen Mai Aly Abhinav Goyal Hassan Awada Mohammad Fahad Asad Teodora Kuzmanovic Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Kenichi Chiba Hiroko Tanaka Yuichi Shiraishi Satoru Miyano Sudipto Mukherjee Thomas LaFramboise Aziz Nazha Mikkael A. Sekeres Tomas Radivoyevitch Torsten Haferlach Seishi Ogawa Jaroslaw P. Maciejewski Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| description |
Stepwise acquisition of mutations gives rise to myelodysplastic syndrome (MDS) in older adults. Here, the authors infer the clonal hierarchy of 1809 MDS patients, revealing insights into the evolution of dominant/secondary mutations and how these impact clinical phenotypes like leukemic progression and therapy response. |
| format |
article |
| author |
Yasunobu Nagata Hideki Makishima Cassandra M. Kerr Bartlomiej P. Przychodzen Mai Aly Abhinav Goyal Hassan Awada Mohammad Fahad Asad Teodora Kuzmanovic Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Kenichi Chiba Hiroko Tanaka Yuichi Shiraishi Satoru Miyano Sudipto Mukherjee Thomas LaFramboise Aziz Nazha Mikkael A. Sekeres Tomas Radivoyevitch Torsten Haferlach Seishi Ogawa Jaroslaw P. Maciejewski |
| author_facet |
Yasunobu Nagata Hideki Makishima Cassandra M. Kerr Bartlomiej P. Przychodzen Mai Aly Abhinav Goyal Hassan Awada Mohammad Fahad Asad Teodora Kuzmanovic Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Kenichi Chiba Hiroko Tanaka Yuichi Shiraishi Satoru Miyano Sudipto Mukherjee Thomas LaFramboise Aziz Nazha Mikkael A. Sekeres Tomas Radivoyevitch Torsten Haferlach Seishi Ogawa Jaroslaw P. Maciejewski |
| author_sort |
Yasunobu Nagata |
| title |
Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| title_short |
Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| title_full |
Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| title_fullStr |
Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| title_full_unstemmed |
Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| title_sort |
invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/37f1f1df587f487aa52451ea6ac3c346 |
| work_keys_str_mv |
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