LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

Cyclin D1 is involved in tamoxifen resistance in breast cancer (BC) but how it is regulated is unclear. Here, the authors demonstrate that the LncRNA DILA1 contributes to tamoxifen resistance in breast cancer by binding to Cyclin D1 and preventing its degradation.

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Autores principales:	Qianfeng Shi, Yudong Li, Shunying Li, Liang Jin, Hongna Lai, Yanqing Wu, Zijie Cai, Mengdi Zhu, Qian Li, Ying Li, Jingru Wang, Yujie Liu, Zongqi Wu, Erwei Song, Qiang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37f72cf52027467ca19fd566a8fd2abd
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spelling	oai:doaj.org-article:37f72cf52027467ca19fd566a8fd2abd2021-12-02T15:39:16ZLncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer10.1038/s41467-020-19349-w2041-1723https://doaj.org/article/37f72cf52027467ca19fd566a8fd2abd2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19349-whttps://doaj.org/toc/2041-1723Cyclin D1 is involved in tamoxifen resistance in breast cancer (BC) but how it is regulated is unclear. Here, the authors demonstrate that the LncRNA DILA1 contributes to tamoxifen resistance in breast cancer by binding to Cyclin D1 and preventing its degradation.Qianfeng ShiYudong LiShunying LiLiang JinHongna LaiYanqing WuZijie CaiMengdi ZhuQian LiYing LiJingru WangYujie LiuZongqi WuErwei SongQiang LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qianfeng Shi Yudong Li Shunying Li Liang Jin Hongna Lai Yanqing Wu Zijie Cai Mengdi Zhu Qian Li Ying Li Jingru Wang Yujie Liu Zongqi Wu Erwei Song Qiang Liu LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
description	Cyclin D1 is involved in tamoxifen resistance in breast cancer (BC) but how it is regulated is unclear. Here, the authors demonstrate that the LncRNA DILA1 contributes to tamoxifen resistance in breast cancer by binding to Cyclin D1 and preventing its degradation.
format	article
author	Qianfeng Shi Yudong Li Shunying Li Liang Jin Hongna Lai Yanqing Wu Zijie Cai Mengdi Zhu Qian Li Ying Li Jingru Wang Yujie Liu Zongqi Wu Erwei Song Qiang Liu
author_facet	Qianfeng Shi Yudong Li Shunying Li Liang Jin Hongna Lai Yanqing Wu Zijie Cai Mengdi Zhu Qian Li Ying Li Jingru Wang Yujie Liu Zongqi Wu Erwei Song Qiang Liu
author_sort	Qianfeng Shi
title	LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
title_short	LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
title_full	LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
title_fullStr	LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
title_full_unstemmed	LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
title_sort	lncrna dila1 inhibits cyclin d1 degradation and contributes to tamoxifen resistance in breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/37f72cf52027467ca19fd566a8fd2abd
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LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

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