Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes

Abstract Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total...

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Autores principales:	Mitsuru Arima, Shintaro Nakao, Yoshihiro Kaizu, Iori Wada, Muneo Yamaguchi, Kohta Fujiwara, Masato Akiyama, Alan W. Stitt, Koh-Hei Sonoda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37f7e809387e4075a31c884a90526062
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spelling	oai:doaj.org-article:37f7e809387e4075a31c884a905260622021-12-02T14:03:57ZDiabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes10.1038/s41598-021-83334-62045-2322https://doaj.org/article/37f7e809387e4075a31c884a905260622021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83334-6https://doaj.org/toc/2045-2322Abstract Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total, superficial, and deep capillary plexus layers (TCP, SCP, and DCP) by optical coherence tomography angiography. All measurement points were classified into four categories according to intensity of fluorescein leakage and FD, and the RS reduction was compared. A stratified analysis by retinal thickness (RT) was also performed. Fourteen eyes (14 patients) were enrolled. FDs at 207 RS measurement points were analyzable. For TCP, SCP and DCP, the leakage did not decrease RS at points where FD was maintained. The greater the leakage, the smaller the RS reduction at points with low FD in TCP (P = .020). Points with high leakage showed a significant smaller RS reduction than points with low leakage (P = .001 for TCP, P = .040 for SCP, and P = .046 for DCP) only in areas with low RT and low FD. Our results suggested that vascular hyperpermeability may inhibit the RS reduction in the non-edematous ischemic diabetic retina.Mitsuru ArimaShintaro NakaoYoshihiro KaizuIori WadaMuneo YamaguchiKohta FujiwaraMasato AkiyamaAlan W. StittKoh-Hei SonodaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mitsuru Arima Shintaro Nakao Yoshihiro Kaizu Iori Wada Muneo Yamaguchi Kohta Fujiwara Masato Akiyama Alan W. Stitt Koh-Hei Sonoda Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
description	Abstract Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total, superficial, and deep capillary plexus layers (TCP, SCP, and DCP) by optical coherence tomography angiography. All measurement points were classified into four categories according to intensity of fluorescein leakage and FD, and the RS reduction was compared. A stratified analysis by retinal thickness (RT) was also performed. Fourteen eyes (14 patients) were enrolled. FDs at 207 RS measurement points were analyzable. For TCP, SCP and DCP, the leakage did not decrease RS at points where FD was maintained. The greater the leakage, the smaller the RS reduction at points with low FD in TCP (P = .020). Points with high leakage showed a significant smaller RS reduction than points with low leakage (P = .001 for TCP, P = .040 for SCP, and P = .046 for DCP) only in areas with low RT and low FD. Our results suggested that vascular hyperpermeability may inhibit the RS reduction in the non-edematous ischemic diabetic retina.
format	article
author	Mitsuru Arima Shintaro Nakao Yoshihiro Kaizu Iori Wada Muneo Yamaguchi Kohta Fujiwara Masato Akiyama Alan W. Stitt Koh-Hei Sonoda
author_facet	Mitsuru Arima Shintaro Nakao Yoshihiro Kaizu Iori Wada Muneo Yamaguchi Kohta Fujiwara Masato Akiyama Alan W. Stitt Koh-Hei Sonoda
author_sort	Mitsuru Arima
title	Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
title_short	Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
title_full	Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
title_fullStr	Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
title_full_unstemmed	Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
title_sort	diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37f7e809387e4075a31c884a90526062
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Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes

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