The Potential Translational Applications of Nanoparticles in Endodontics

Jasmine Wong, Ting Zou, Angeline Hui Cheng Lee, Chengfei Zhang Restorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative RegionCorrespondence: Chengfei ZhangRestorative Dental Sciences (Endodontics), Faculty of Dentistry, The Unive...

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Autores principales:	Wong J, Zou T, Lee AHC, Zhang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nanoparticles endodontics translational research disinfection obturation regenerative procedures Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3800e7440037412da173de079ba0a148
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spelling	oai:doaj.org-article:3800e7440037412da173de079ba0a1482021-12-02T13:26:20ZThe Potential Translational Applications of Nanoparticles in Endodontics1178-2013https://doaj.org/article/3800e7440037412da173de079ba0a1482021-03-01T00:00:00Zhttps://www.dovepress.com/the-potential-translational-applications-of-nanoparticles-in-endodonti-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jasmine Wong, Ting Zou, Angeline Hui Cheng Lee, Chengfei Zhang Restorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative RegionCorrespondence: Chengfei ZhangRestorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Floor 3B60, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong KongTel +852-2859-0371Fax +852-2559-9013Email zhangcf@hku.hkAbstract: Nanotechnology has substantially progressed in the past decades, giving rise to numerous possible applications in different biomedical fields. In particular, the use of nanoparticles in endodontics has generated significant interest due to their unique characteristics. As a result of their nanoscale dimensions, nanoparticles possess several properties that may enhance the treatment of endodontic infections, such as heightened antibacterial activity, increased reactivity and the capacity to be functionalized with other reactive compounds. Effective disinfection and sealing of the root canal system are the hallmarks for successful endodontic treatment. However, the presence of bacterial biofilms and resistance to endodontic disinfectants pose a significant challenge to this goal. This has encouraged the investigation of antibacterial nanoparticle-based irrigants and intracanal medicaments, which may improve the elimination of endodontic infections. In addition, photosynthesizer-functionalized nanoparticles could also serve as a worthy adjunct to root canal disinfection strategies. Furthermore, despite the myriad of commercially available options for endodontic obturation, the “ideal” material has yet to be conceived. This has led to the development of various experimental nanoparticle-incorporated obturation materials and sealers that exhibit a range of favourable physicochemical properties including enhanced antibacterial efficacy and bioactivity. Nanoparticle applications also show promise in the field of regenerative endodontics, such as supporting the release of bioactive molecules and enhancing the biophysical properties of scaffolds. Given the constantly growing body of research in this field, this article aims to present an overview of the current evidence pertaining to the potential translational applications of nanoparticles in endodontics.Keywords: nanoparticles, endodontics, translational research, disinfection, obturation, regenerative proceduresWong JZou TLee AHCZhang CDove Medical Pressarticlenanoparticlesendodonticstranslational researchdisinfectionobturationregenerative proceduresMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2087-2106 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles endodontics translational research disinfection obturation regenerative procedures Medicine (General) R5-920
spellingShingle	nanoparticles endodontics translational research disinfection obturation regenerative procedures Medicine (General) R5-920 Wong J Zou T Lee AHC Zhang C The Potential Translational Applications of Nanoparticles in Endodontics
description	Jasmine Wong, Ting Zou, Angeline Hui Cheng Lee, Chengfei Zhang Restorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative RegionCorrespondence: Chengfei ZhangRestorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Floor 3B60, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong KongTel +852-2859-0371Fax +852-2559-9013Email zhangcf@hku.hkAbstract: Nanotechnology has substantially progressed in the past decades, giving rise to numerous possible applications in different biomedical fields. In particular, the use of nanoparticles in endodontics has generated significant interest due to their unique characteristics. As a result of their nanoscale dimensions, nanoparticles possess several properties that may enhance the treatment of endodontic infections, such as heightened antibacterial activity, increased reactivity and the capacity to be functionalized with other reactive compounds. Effective disinfection and sealing of the root canal system are the hallmarks for successful endodontic treatment. However, the presence of bacterial biofilms and resistance to endodontic disinfectants pose a significant challenge to this goal. This has encouraged the investigation of antibacterial nanoparticle-based irrigants and intracanal medicaments, which may improve the elimination of endodontic infections. In addition, photosynthesizer-functionalized nanoparticles could also serve as a worthy adjunct to root canal disinfection strategies. Furthermore, despite the myriad of commercially available options for endodontic obturation, the “ideal” material has yet to be conceived. This has led to the development of various experimental nanoparticle-incorporated obturation materials and sealers that exhibit a range of favourable physicochemical properties including enhanced antibacterial efficacy and bioactivity. Nanoparticle applications also show promise in the field of regenerative endodontics, such as supporting the release of bioactive molecules and enhancing the biophysical properties of scaffolds. Given the constantly growing body of research in this field, this article aims to present an overview of the current evidence pertaining to the potential translational applications of nanoparticles in endodontics.Keywords: nanoparticles, endodontics, translational research, disinfection, obturation, regenerative procedures
format	article
author	Wong J Zou T Lee AHC Zhang C
author_facet	Wong J Zou T Lee AHC Zhang C
author_sort	Wong J
title	The Potential Translational Applications of Nanoparticles in Endodontics
title_short	The Potential Translational Applications of Nanoparticles in Endodontics
title_full	The Potential Translational Applications of Nanoparticles in Endodontics
title_fullStr	The Potential Translational Applications of Nanoparticles in Endodontics
title_full_unstemmed	The Potential Translational Applications of Nanoparticles in Endodontics
title_sort	potential translational applications of nanoparticles in endodontics
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/3800e7440037412da173de079ba0a148
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The Potential Translational Applications of Nanoparticles in Endodontics

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