OCTA reveals remodeling of the peripheral capillary free zones in normal aging

Abstract The retinal neurovascular unit consists of blood vessel endothelial cells, pericytes, neurons, astrocytes, and Müller cells that form the inner retinal blood barrier. A peripheral capillary free zone (pCFZ) represents the distance that oxygen and nutrients must diffuse to reach the neural r...

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Autores principales:	Edmund Arthur, Jessica Alber, Louisa I. Thompson, Stuart Sinoff, Peter J. Snyder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/380344463a204db3b93b7f269a97e180
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spelling	oai:doaj.org-article:380344463a204db3b93b7f269a97e1802021-12-02T18:49:25ZOCTA reveals remodeling of the peripheral capillary free zones in normal aging10.1038/s41598-021-95230-02045-2322https://doaj.org/article/380344463a204db3b93b7f269a97e1802021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95230-0https://doaj.org/toc/2045-2322Abstract The retinal neurovascular unit consists of blood vessel endothelial cells, pericytes, neurons, astrocytes, and Müller cells that form the inner retinal blood barrier. A peripheral capillary free zone (pCFZ) represents the distance that oxygen and nutrients must diffuse to reach the neural retina, and serves as a metric of retinal tissue oxygenation. The pCFZs are formed based on oxygen saturation in the retinal arterioles and venules. Because retinal arterioles contain a larger concentration of oxygenated blood than venules, there is a reduced need for capillaries to exist closely to arterioles compared to venules. Therefore, in a healthy individual, larger periarteriole CFZs are expected compared to perivenule CFZs. With normal aging, there is atrophy of the inner retinal neurons, and consequently reduced extraction of oxygen and nutrients from the retinal vessels (i.e., increased oxygen saturation). Therefore, we hypothesized that the peripheral CFZ will remodel with normal aging. Using Optical Coherence Tomography Angiography, we showed that the pCFZs do remodel in normal aging with large (perivenule: η2 p = 0.56) and moderate (periarteriole: η2 p = 0.12) effect sizes, opening the possibility that such changes may be further increased by neurodegenerative diseases that adversely impact the health of the retinal neural cell layers.Edmund ArthurJessica AlberLouisa I. ThompsonStuart SinoffPeter J. SnyderNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Edmund Arthur Jessica Alber Louisa I. Thompson Stuart Sinoff Peter J. Snyder OCTA reveals remodeling of the peripheral capillary free zones in normal aging
description	Abstract The retinal neurovascular unit consists of blood vessel endothelial cells, pericytes, neurons, astrocytes, and Müller cells that form the inner retinal blood barrier. A peripheral capillary free zone (pCFZ) represents the distance that oxygen and nutrients must diffuse to reach the neural retina, and serves as a metric of retinal tissue oxygenation. The pCFZs are formed based on oxygen saturation in the retinal arterioles and venules. Because retinal arterioles contain a larger concentration of oxygenated blood than venules, there is a reduced need for capillaries to exist closely to arterioles compared to venules. Therefore, in a healthy individual, larger periarteriole CFZs are expected compared to perivenule CFZs. With normal aging, there is atrophy of the inner retinal neurons, and consequently reduced extraction of oxygen and nutrients from the retinal vessels (i.e., increased oxygen saturation). Therefore, we hypothesized that the peripheral CFZ will remodel with normal aging. Using Optical Coherence Tomography Angiography, we showed that the pCFZs do remodel in normal aging with large (perivenule: η2 p = 0.56) and moderate (periarteriole: η2 p = 0.12) effect sizes, opening the possibility that such changes may be further increased by neurodegenerative diseases that adversely impact the health of the retinal neural cell layers.
format	article
author	Edmund Arthur Jessica Alber Louisa I. Thompson Stuart Sinoff Peter J. Snyder
author_facet	Edmund Arthur Jessica Alber Louisa I. Thompson Stuart Sinoff Peter J. Snyder
author_sort	Edmund Arthur
title	OCTA reveals remodeling of the peripheral capillary free zones in normal aging
title_short	OCTA reveals remodeling of the peripheral capillary free zones in normal aging
title_full	OCTA reveals remodeling of the peripheral capillary free zones in normal aging
title_fullStr	OCTA reveals remodeling of the peripheral capillary free zones in normal aging
title_full_unstemmed	OCTA reveals remodeling of the peripheral capillary free zones in normal aging
title_sort	octa reveals remodeling of the peripheral capillary free zones in normal aging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/380344463a204db3b93b7f269a97e180
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OCTA reveals remodeling of the peripheral capillary free zones in normal aging

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