Deacetoxycephalosporin C synthase (expandase): Research progress and application potential

Cephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of cephalosporin. DAOCS in fungus Acremonium chrysog...

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Autores principales:	Xiaofan Niu, Jian Zhang, Xianli Xue, Depei Wang, Lin Wang, Qiang Gao
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Deacetyloxycephalosporin C synthase Expandase Streptomyces clavuligerus Acremonium chrysogenum Progress Application Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3804745428b74c0d84876ec567571e1a
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id	oai:doaj.org-article:3804745428b74c0d84876ec567571e1a
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spelling	oai:doaj.org-article:3804745428b74c0d84876ec567571e1a2021-11-24T04:32:32ZDeacetoxycephalosporin C synthase (expandase): Research progress and application potential2405-805X10.1016/j.synbio.2021.11.001https://doaj.org/article/3804745428b74c0d84876ec567571e1a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405805X21000697https://doaj.org/toc/2405-805XCephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of cephalosporin. DAOCS in fungus Acremonium chrysogenum was identified as a bifunctional enzyme with both ring expansion and hydroxylation, whereas two separate enzymes in bacteria catalyze these two reactions. In this review, we briefly summarize its source and function, improvement of the conversion rate of penicillin to deacetyloxycephalosporin C through enzyme modification, crystallography features, the prediction of the active site, and application perspective.Xiaofan NiuJian ZhangXianli XueDepei WangLin WangQiang GaoKeAi Communications Co., Ltd.articleDeacetyloxycephalosporin C synthaseExpandaseStreptomyces clavuligerusAcremonium chrysogenumProgressApplicationBiotechnologyTP248.13-248.65Biology (General)QH301-705.5ENSynthetic and Systems Biotechnology, Vol 6, Iss 4, Pp 396-401 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Deacetyloxycephalosporin C synthase Expandase Streptomyces clavuligerus Acremonium chrysogenum Progress Application Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
spellingShingle	Deacetyloxycephalosporin C synthase Expandase Streptomyces clavuligerus Acremonium chrysogenum Progress Application Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Xiaofan Niu Jian Zhang Xianli Xue Depei Wang Lin Wang Qiang Gao Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
description	Cephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of cephalosporin. DAOCS in fungus Acremonium chrysogenum was identified as a bifunctional enzyme with both ring expansion and hydroxylation, whereas two separate enzymes in bacteria catalyze these two reactions. In this review, we briefly summarize its source and function, improvement of the conversion rate of penicillin to deacetyloxycephalosporin C through enzyme modification, crystallography features, the prediction of the active site, and application perspective.
format	article
author	Xiaofan Niu Jian Zhang Xianli Xue Depei Wang Lin Wang Qiang Gao
author_facet	Xiaofan Niu Jian Zhang Xianli Xue Depei Wang Lin Wang Qiang Gao
author_sort	Xiaofan Niu
title	Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
title_short	Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
title_full	Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
title_fullStr	Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
title_full_unstemmed	Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
title_sort	deacetoxycephalosporin c synthase (expandase): research progress and application potential
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/3804745428b74c0d84876ec567571e1a
work_keys_str_mv	AT xiaofanniu deacetoxycephalosporincsynthaseexpandaseresearchprogressandapplicationpotential AT jianzhang deacetoxycephalosporincsynthaseexpandaseresearchprogressandapplicationpotential AT xianlixue deacetoxycephalosporincsynthaseexpandaseresearchprogressandapplicationpotential AT depeiwang deacetoxycephalosporincsynthaseexpandaseresearchprogressandapplicationpotential AT linwang deacetoxycephalosporincsynthaseexpandaseresearchprogressandapplicationpotential AT qianggao deacetoxycephalosporincsynthaseexpandaseresearchprogressandapplicationpotential
_version_	1718415969131429888

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential

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