Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development

Abstract The prevalence of overweight and obesity amongst reproductive women has been increasing worldwide. Our aim was to compare pregnancy outcomes and infant neurocognitive development by different BMI classifications and investigate whether early pregnancy BMI was associated with risks of advers...

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Autores principales:	Yu-Ting Chen, Ting Zhang, Chang Chen, Yin-Yin Xia, Ting-Li Han, Xu-Yang Chen, Xiao-Ling He, Ge Xu, Zhen Zou, Hong-Bo Qi, Hua Zhang, Benjamin B. Albert, John Colombo, Philip N. Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38086e53bd8b4dfd8180a1e9f89d115d
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spelling	oai:doaj.org-article:38086e53bd8b4dfd8180a1e9f89d115d2021-12-02T14:03:44ZAssociations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development10.1038/s41598-021-83430-72045-2322https://doaj.org/article/38086e53bd8b4dfd8180a1e9f89d115d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83430-7https://doaj.org/toc/2045-2322Abstract The prevalence of overweight and obesity amongst reproductive women has been increasing worldwide. Our aim was to compare pregnancy outcomes and infant neurocognitive development by different BMI classifications and investigate whether early pregnancy BMI was associated with risks of adverse outcomes in a Southwest Chinese population. We analysed data from 1273 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) randomized controlled trial in Chongqing, China. Maternal BMI was classified as underweight, normal weight and overweight/obese according to the Chinese, WHO Asian, and WHO European standards. For the adverse pregnancy outcomes, after adjustment for potential confounders, an underweight BMI was associated with increased risk of small for gestational age (SGA) babies, and an overweight/obese BMI was associated with increased risk of maternal gestational diabetes mellitus (GDM), caesarean section (C-section), macrosomia and large for gestational age (LGA) babies. For infant neurocognitive development, 1017 mothers and their children participated; no significant differences were seen in the Mental Development Index (MDI) or the Psychomotor Development Index (PDI) between the three BMI groups. Our findings demonstrate that abnormal early pregnancy BMI were associated with increased risks of adverse pregnancy outcomes in Chinese women, while early pregnancy BMI had no significant influence on the infant neurocognitive development at 12 months of age.Yu-Ting ChenTing ZhangChang ChenYin-Yin XiaTing-Li HanXu-Yang ChenXiao-Ling HeGe XuZhen ZouHong-Bo QiHua ZhangBenjamin B. AlbertJohn ColomboPhilip N. BakerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Ting Chen Ting Zhang Chang Chen Yin-Yin Xia Ting-Li Han Xu-Yang Chen Xiao-Ling He Ge Xu Zhen Zou Hong-Bo Qi Hua Zhang Benjamin B. Albert John Colombo Philip N. Baker Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development
description	Abstract The prevalence of overweight and obesity amongst reproductive women has been increasing worldwide. Our aim was to compare pregnancy outcomes and infant neurocognitive development by different BMI classifications and investigate whether early pregnancy BMI was associated with risks of adverse outcomes in a Southwest Chinese population. We analysed data from 1273 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) randomized controlled trial in Chongqing, China. Maternal BMI was classified as underweight, normal weight and overweight/obese according to the Chinese, WHO Asian, and WHO European standards. For the adverse pregnancy outcomes, after adjustment for potential confounders, an underweight BMI was associated with increased risk of small for gestational age (SGA) babies, and an overweight/obese BMI was associated with increased risk of maternal gestational diabetes mellitus (GDM), caesarean section (C-section), macrosomia and large for gestational age (LGA) babies. For infant neurocognitive development, 1017 mothers and their children participated; no significant differences were seen in the Mental Development Index (MDI) or the Psychomotor Development Index (PDI) between the three BMI groups. Our findings demonstrate that abnormal early pregnancy BMI were associated with increased risks of adverse pregnancy outcomes in Chinese women, while early pregnancy BMI had no significant influence on the infant neurocognitive development at 12 months of age.
format	article
author	Yu-Ting Chen Ting Zhang Chang Chen Yin-Yin Xia Ting-Li Han Xu-Yang Chen Xiao-Ling He Ge Xu Zhen Zou Hong-Bo Qi Hua Zhang Benjamin B. Albert John Colombo Philip N. Baker
author_facet	Yu-Ting Chen Ting Zhang Chang Chen Yin-Yin Xia Ting-Li Han Xu-Yang Chen Xiao-Ling He Ge Xu Zhen Zou Hong-Bo Qi Hua Zhang Benjamin B. Albert John Colombo Philip N. Baker
author_sort	Yu-Ting Chen
title	Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development
title_short	Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development
title_full	Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development
title_fullStr	Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development
title_full_unstemmed	Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development
title_sort	associations of early pregnancy bmi with adverse pregnancy outcomes and infant neurocognitive development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/38086e53bd8b4dfd8180a1e9f89d115d
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Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development

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