Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Chronic hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) and is associated with immune tolerance to HBV. Here the authors show, in a transgenic mouse model, that rescuing T cells function via inhibition of co-inhibitory receptor TIGIT results in HCC development v...

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Autores principales: Lu Zong, Hui Peng, Cheng Sun, Fenglei Li, Meijuan Zheng, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3809ac5712f745caba55aa8c7a7c2156
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spelling oai:doaj.org-article:3809ac5712f745caba55aa8c7a7c21562021-12-02T16:57:23ZBreakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice10.1038/s41467-018-08096-82041-1723https://doaj.org/article/3809ac5712f745caba55aa8c7a7c21562019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08096-8https://doaj.org/toc/2041-1723Chronic hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) and is associated with immune tolerance to HBV. Here the authors show, in a transgenic mouse model, that rescuing T cells function via inhibition of co-inhibitory receptor TIGIT results in HCC development via supporting inflammation.Lu ZongHui PengCheng SunFenglei LiMeijuan ZhengYongyan ChenHaiming WeiRui SunZhigang TianNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lu Zong
Hui Peng
Cheng Sun
Fenglei Li
Meijuan Zheng
Yongyan Chen
Haiming Wei
Rui Sun
Zhigang Tian
Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice
description Chronic hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) and is associated with immune tolerance to HBV. Here the authors show, in a transgenic mouse model, that rescuing T cells function via inhibition of co-inhibitory receptor TIGIT results in HCC development via supporting inflammation.
format article
author Lu Zong
Hui Peng
Cheng Sun
Fenglei Li
Meijuan Zheng
Yongyan Chen
Haiming Wei
Rui Sun
Zhigang Tian
author_facet Lu Zong
Hui Peng
Cheng Sun
Fenglei Li
Meijuan Zheng
Yongyan Chen
Haiming Wei
Rui Sun
Zhigang Tian
author_sort Lu Zong
title Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice
title_short Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice
title_full Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice
title_fullStr Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice
title_full_unstemmed Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice
title_sort breakdown of adaptive immunotolerance induces hepatocellular carcinoma in hbsag-tg mice
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3809ac5712f745caba55aa8c7a7c2156
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AT huipeng breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT chengsun breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT fengleili breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT meijuanzheng breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT yongyanchen breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT haimingwei breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT ruisun breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
AT zhigangtian breakdownofadaptiveimmunotoleranceinduceshepatocellularcarcinomainhbsagtgmice
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