Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Chronic hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) and is associated with immune tolerance to HBV. Here the authors show, in a transgenic mouse model, that rescuing T cells function via inhibition of co-inhibitory receptor TIGIT results in HCC development v...

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Autores principales: Lu Zong, Hui Peng, Cheng Sun, Fenglei Li, Meijuan Zheng, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/3809ac5712f745caba55aa8c7a7c2156
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