T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire diversity, and more repertoire sharing than those from...

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Autores principales:	Iria Gomez-Tourino, Yogesh Kamra, Roman Baptista, Anna Lorenc, Mark Peakman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/380b4cadc81944b194b1293a9b9b42f5
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spelling	oai:doaj.org-article:380b4cadc81944b194b1293a9b9b42f52021-12-02T14:42:37ZT cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes10.1038/s41467-017-01925-22041-1723https://doaj.org/article/380b4cadc81944b194b1293a9b9b42f52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01925-2https://doaj.org/toc/2041-1723T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire diversity, and more repertoire sharing than those from healthy individuals.Iria Gomez-TourinoYogesh KamraRoman BaptistaAnna LorencMark PeakmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iria Gomez-Tourino Yogesh Kamra Roman Baptista Anna Lorenc Mark Peakman T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
description	T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire diversity, and more repertoire sharing than those from healthy individuals.
format	article
author	Iria Gomez-Tourino Yogesh Kamra Roman Baptista Anna Lorenc Mark Peakman
author_facet	Iria Gomez-Tourino Yogesh Kamra Roman Baptista Anna Lorenc Mark Peakman
author_sort	Iria Gomez-Tourino
title	T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
title_short	T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
title_full	T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
title_fullStr	T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
title_full_unstemmed	T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
title_sort	t cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/380b4cadc81944b194b1293a9b9b42f5
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T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

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