Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic

Abstract This review describes the evidence for the potential benefit of vitamin D supplementation in people with respiratory diseases who may have a higher susceptibility to coronavirus disease 2019 (COVID‐19) infection and its consequences. Clinical evidence indicates that vitamin D may reduce the...

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Autores principales:	Vasudevan V. Chetty, Manoranjenni Chetty
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/380baa1a6b4c44b7be0fd47e5fb10a99
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spelling	oai:doaj.org-article:380baa1a6b4c44b7be0fd47e5fb10a992021-11-19T17:51:34ZPotential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic1752-80621752-805410.1111/cts.13044https://doaj.org/article/380baa1a6b4c44b7be0fd47e5fb10a992021-11-01T00:00:00Zhttps://doi.org/10.1111/cts.13044https://doaj.org/toc/1752-8054https://doaj.org/toc/1752-8062Abstract This review describes the evidence for the potential benefit of vitamin D supplementation in people with respiratory diseases who may have a higher susceptibility to coronavirus disease 2019 (COVID‐19) infection and its consequences. Clinical evidence indicates that vitamin D may reduce the risk of both upper and lower respiratory tract infections and offers benefit particularly in people with vitamin D deficiency. Some evidence exists for a higher incidence of active tuberculosis (TB) in patients who are deficient in vitamin D. An association between low levels of 25(OH)D (the active form of vitamin D) and COVID‐19 severity of illness and mortality has also been reported. In addition, low 25(OH)D levels are associated with poor outcomes in acute respiratory distress syndrome (ARDS). The cytokine storm experienced in severe COVID‐19 infections results from excessive release of pro‐inflammatory cytokines. Due to its immunomodulatory effects, adequate vitamin D levels may cause a decrease in the pro‐inflammatory cytokines and an increase in the anti‐inflammatory cytokines during COVID‐19 infections. Vitamin D deficiency was found in 82.2% of hospitalized COVID‐19 cases and 47.2% of population‐based controls (p < 0.0001). The available evidence warrants an evaluation of vitamin D supplementation in susceptible populations with respiratory diseases, such as TB, and particularly in those who are deficient in vitamin D. This may mitigate against serious complications of COVID‐19 infections or reduce the impact of ARDS in those who have been infected.Vasudevan V. ChettyManoranjenni ChettyWileyarticleTherapeutics. PharmacologyRM1-950Public aspects of medicineRA1-1270ENClinical and Translational Science, Vol 14, Iss 6, Pp 2111-2116 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
spellingShingle	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270 Vasudevan V. Chetty Manoranjenni Chetty Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic
description	Abstract This review describes the evidence for the potential benefit of vitamin D supplementation in people with respiratory diseases who may have a higher susceptibility to coronavirus disease 2019 (COVID‐19) infection and its consequences. Clinical evidence indicates that vitamin D may reduce the risk of both upper and lower respiratory tract infections and offers benefit particularly in people with vitamin D deficiency. Some evidence exists for a higher incidence of active tuberculosis (TB) in patients who are deficient in vitamin D. An association between low levels of 25(OH)D (the active form of vitamin D) and COVID‐19 severity of illness and mortality has also been reported. In addition, low 25(OH)D levels are associated with poor outcomes in acute respiratory distress syndrome (ARDS). The cytokine storm experienced in severe COVID‐19 infections results from excessive release of pro‐inflammatory cytokines. Due to its immunomodulatory effects, adequate vitamin D levels may cause a decrease in the pro‐inflammatory cytokines and an increase in the anti‐inflammatory cytokines during COVID‐19 infections. Vitamin D deficiency was found in 82.2% of hospitalized COVID‐19 cases and 47.2% of population‐based controls (p < 0.0001). The available evidence warrants an evaluation of vitamin D supplementation in susceptible populations with respiratory diseases, such as TB, and particularly in those who are deficient in vitamin D. This may mitigate against serious complications of COVID‐19 infections or reduce the impact of ARDS in those who have been infected.
format	article
author	Vasudevan V. Chetty Manoranjenni Chetty
author_facet	Vasudevan V. Chetty Manoranjenni Chetty
author_sort	Vasudevan V. Chetty
title	Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic
title_short	Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic
title_full	Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic
title_fullStr	Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic
title_full_unstemmed	Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic
title_sort	potential benefit of vitamin d supplementation in people with respiratory illnesses, during the covid‐19 pandemic
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/380baa1a6b4c44b7be0fd47e5fb10a99
work_keys_str_mv	AT vasudevanvchetty potentialbenefitofvitamindsupplementationinpeoplewithrespiratoryillnessesduringthecovid19pandemic AT manoranjennichetty potentialbenefitofvitamindsupplementationinpeoplewithrespiratoryillnessesduringthecovid19pandemic
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Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemic

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