Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy

Abstract The human chaperonin TRiC consists of eight non-identical subunits, and its protein-folding activity is critical for cellular health. Misfolded proteins are associated with many human diseases, such as amyloid diseases, cancer, and neuropathies, making TRiC a potential therapeutic target. A...

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Auteurs principaux: Jose H. Pereira, Ryan P. McAndrew, Oksana A. Sergeeva, Corie Y. Ralston, Jonathan A. King, Paul D. Adams
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/380cea13dfbc4d1c99c09ee67ecb6f29
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