Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.

Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.

During B cell development, the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin κ light chain (Igκ) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline V(κ) transcripti...

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Autores principales: Ralph Stadhouders, Marjolein J W de Bruijn, Magdalena B Rother, Saravanan Yuvaraj, Claudia Ribeiro de Almeida, Petros Kolovos, Menno C Van Zelm, Wilfred van Ijcken, Frank Grosveld, Eric Soler, Rudi W Hendriks
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/380d635fd7a8458da581a6733d653c20
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