Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.

Cancer associated fibroblasts (CAFs) are responsible for tumor growth, angiogenesis, invasion, and metastasis. Matrix metalloproteinase (MMP)-9 secreted from cancer stroma populated by CAFs is a prerequisite for cancer angiogenesis and metastasis. Omega-3 polyunsaturated fatty acids (omega-3 PUFA) h...

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Main Authors:	Ayumi Taguchi, Kei Kawana, Kensuke Tomio, Aki Yamashita, Yosuke Isobe, Kazunori Nagasaka, Kaori Koga, Tomoko Inoue, Haruka Nishida, Satoko Kojima, Katsuyuki Adachi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Jing X Kang, Hiroyuki Arai, Makoto Arita, Yutaka Osuga, Tomoyuki Fujii
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2014
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/380d84cde8e340c4b51e82397041f59f
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Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.

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