Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the requir...

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Autores principales:	Jinwook Kim, Brooks D. Lindsey, Wei-Yi Chang, Xuming Dai, Joseph M. Stavas, Paul A. Dayton, Xiaoning Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/380f5c38f1464df3b2af21c25b4faad3
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spelling	oai:doaj.org-article:380f5c38f1464df3b2af21c25b4faad32021-12-02T15:06:23ZIntravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis10.1038/s41598-017-03492-42045-2322https://doaj.org/article/380f5c38f1464df3b2af21c25b4faad32017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03492-4https://doaj.org/toc/2045-2322Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.Jinwook KimBrooks D. LindseyWei-Yi ChangXuming DaiJoseph M. StavasPaul A. DaytonXiaoning JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinwook Kim Brooks D. Lindsey Wei-Yi Chang Xuming Dai Joseph M. Stavas Paul A. Dayton Xiaoning Jiang Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
description	Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.
format	article
author	Jinwook Kim Brooks D. Lindsey Wei-Yi Chang Xuming Dai Joseph M. Stavas Paul A. Dayton Xiaoning Jiang
author_facet	Jinwook Kim Brooks D. Lindsey Wei-Yi Chang Xuming Dai Joseph M. Stavas Paul A. Dayton Xiaoning Jiang
author_sort	Jinwook Kim
title	Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
title_short	Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
title_full	Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
title_fullStr	Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
title_full_unstemmed	Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
title_sort	intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/380f5c38f1464df3b2af21c25b4faad3
work_keys_str_mv	AT jinwookkim intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis AT brooksdlindsey intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis AT weiyichang intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis AT xumingdai intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis AT josephmstavas intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis AT pauladayton intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis AT xiaoningjiang intravascularforwardlookingultrasoundtransducersformicrobubblemediatedsonothrombolysis
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Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

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