ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
Chronic viral hepatitis C is the most common cause of liver damage and the global problem worldwide since is characterized by a high prevalence, high chronization rates, and significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. Many studies have shown that antigen-specifi...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3813429c8f4d436688a35d4b0d57bd8a |
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| Sumario: | Chronic viral hepatitis C is the most common cause of liver damage and the global problem worldwide since is characterized by a high prevalence, high chronization rates, and significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. Many studies have shown that antigen-specific СD4+ and CD8+T-cells play a key role in pathogenesis and outcome of the infection. While the strong sustained antigenspecific multi-epitopic T-cell response predicts successful viral elimination, a deficiency of adaptive immune response is associated with virus persistence. This review presents data about pathogenetic significance of T-cell response in viral elimination, viral persistence and hepatitis development. Possible mechanisms of T-cell response failure in chronic infection are discussed as well. |
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