ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION

Chronic viral hepatitis C is the most common cause of liver damage and the global problem worldwide since is characterized by a high prevalence, high chronization rates, and significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. Many studies have shown that antigen-specifi...

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Autores principales:	E. A. Oleynik, O. Yu. Leplina, A. A. Ostanin, N. M. Starostina, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	antigen-specific t-cell response сd8+t-cells cd4+t-cells viral hepatitis c adaptive t-cells response viral antigens Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3813429c8f4d436688a35d4b0d57bd8a
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spelling	oai:doaj.org-article:3813429c8f4d436688a35d4b0d57bd8a2021-11-18T08:03:45ZADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION1563-06252313-741X10.15789/1563-0625-2016-4-309-316https://doaj.org/article/3813429c8f4d436688a35d4b0d57bd8a2016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1053https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XChronic viral hepatitis C is the most common cause of liver damage and the global problem worldwide since is characterized by a high prevalence, high chronization rates, and significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. Many studies have shown that antigen-specific СD4+ and CD8+T-cells play a key role in pathogenesis and outcome of the infection. While the strong sustained antigenspecific multi-epitopic T-cell response predicts successful viral elimination, a deficiency of adaptive immune response is associated with virus persistence. This review presents data about pathogenetic significance of T-cell response in viral elimination, viral persistence and hepatitis development. Possible mechanisms of T-cell response failure in chronic infection are discussed as well.E. A. OleynikO. Yu. LeplinaA. A. OstaninN. M. StarostinaE. R. ChernykhSPb RAACIarticleantigen-specific t-cell responseсd8+t-cellscd4+t-cellsviral hepatitis cadaptive t-cells responseviral antigensImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 4, Pp 309-316 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	antigen-specific t-cell response сd8+t-cells cd4+t-cells viral hepatitis c adaptive t-cells response viral antigens Immunologic diseases. Allergy RC581-607
spellingShingle	antigen-specific t-cell response сd8+t-cells cd4+t-cells viral hepatitis c adaptive t-cells response viral antigens Immunologic diseases. Allergy RC581-607 E. A. Oleynik O. Yu. Leplina A. A. Ostanin N. M. Starostina E. R. Chernykh ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
description	Chronic viral hepatitis C is the most common cause of liver damage and the global problem worldwide since is characterized by a high prevalence, high chronization rates, and significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. Many studies have shown that antigen-specific СD4+ and CD8+T-cells play a key role in pathogenesis and outcome of the infection. While the strong sustained antigenspecific multi-epitopic T-cell response predicts successful viral elimination, a deficiency of adaptive immune response is associated with virus persistence. This review presents data about pathogenetic significance of T-cell response in viral elimination, viral persistence and hepatitis development. Possible mechanisms of T-cell response failure in chronic infection are discussed as well.
format	article
author	E. A. Oleynik O. Yu. Leplina A. A. Ostanin N. M. Starostina E. R. Chernykh
author_facet	E. A. Oleynik O. Yu. Leplina A. A. Ostanin N. M. Starostina E. R. Chernykh
author_sort	E. A. Oleynik
title	ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
title_short	ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
title_full	ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
title_fullStr	ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
title_full_unstemmed	ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION
title_sort	adaptive t-cell response in pathogenesis of hepatitis c infection
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/3813429c8f4d436688a35d4b0d57bd8a
work_keys_str_mv	AT eaoleynik adaptivetcellresponseinpathogenesisofhepatitiscinfection AT oyuleplina adaptivetcellresponseinpathogenesisofhepatitiscinfection AT aaostanin adaptivetcellresponseinpathogenesisofhepatitiscinfection AT nmstarostina adaptivetcellresponseinpathogenesisofhepatitiscinfection AT erchernykh adaptivetcellresponseinpathogenesisofhepatitiscinfection
_version_	1718422409368829952

ADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTION

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