Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.

Cadmium (Cd), one of the heavy metals, is an important environmental pollutant and a potent toxicant to organism. It poses a severe threat to the growth of the organism, and also has been recognized as a human carcinogen. However, the toxicity of cadmium and its influences on microbiota in mammal�...

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Autores principales:	Yehao Liu, Yuhui Li, Kaiyong Liu, Jie Shen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3813632f9e8e4ecba6a67bc9e755093b
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spelling	oai:doaj.org-article:3813632f9e8e4ecba6a67bc9e755093b2021-11-18T08:34:22ZExposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.1932-620310.1371/journal.pone.0085323https://doaj.org/article/3813632f9e8e4ecba6a67bc9e755093b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498261/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cadmium (Cd), one of the heavy metals, is an important environmental pollutant and a potent toxicant to organism. It poses a severe threat to the growth of the organism, and also has been recognized as a human carcinogen. However, the toxicity of cadmium and its influences on microbiota in mammal's intestine are still unclear. In our experiment, the changes of intestinal microbiota in two groups of mice were investigated, which were supplied with 20 and 100 mg kg(-1) cadmium chloride respectively for 3 weeks. The control group was treated with water free from cadmium chloride only. This study demonstrated that Cd accumulated in some tissues of mice after Cd administration and the gut barrier was impaired. Cd exposure also significantly elevated the colonic level of TNF-α. On the other hand, Cd-treatment could slow down the growth of gut microbiota and reduced the abundance of total intestinal bacteria of the mice. Among them, the growth of Bacteroidetes was significantly suppressed while Firmicutes growth was not. The probiotics including Lactobacillus and Bifidobacterium were notably inhibited. We also observed that the copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids (SCFAs) were lower in Cd-treated groups than control. As a result, the levels of short-chain fatty acids in colonic decreased significantly. In summary, this study provides valuable insight into the effects of Cd intake on mice gut microbiota.Yehao LiuYuhui LiKaiyong LiuJie ShenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e85323 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yehao Liu Yuhui Li Kaiyong Liu Jie Shen Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
description	Cadmium (Cd), one of the heavy metals, is an important environmental pollutant and a potent toxicant to organism. It poses a severe threat to the growth of the organism, and also has been recognized as a human carcinogen. However, the toxicity of cadmium and its influences on microbiota in mammal's intestine are still unclear. In our experiment, the changes of intestinal microbiota in two groups of mice were investigated, which were supplied with 20 and 100 mg kg(-1) cadmium chloride respectively for 3 weeks. The control group was treated with water free from cadmium chloride only. This study demonstrated that Cd accumulated in some tissues of mice after Cd administration and the gut barrier was impaired. Cd exposure also significantly elevated the colonic level of TNF-α. On the other hand, Cd-treatment could slow down the growth of gut microbiota and reduced the abundance of total intestinal bacteria of the mice. Among them, the growth of Bacteroidetes was significantly suppressed while Firmicutes growth was not. The probiotics including Lactobacillus and Bifidobacterium were notably inhibited. We also observed that the copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids (SCFAs) were lower in Cd-treated groups than control. As a result, the levels of short-chain fatty acids in colonic decreased significantly. In summary, this study provides valuable insight into the effects of Cd intake on mice gut microbiota.
format	article
author	Yehao Liu Yuhui Li Kaiyong Liu Jie Shen
author_facet	Yehao Liu Yuhui Li Kaiyong Liu Jie Shen
author_sort	Yehao Liu
title	Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
title_short	Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
title_full	Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
title_fullStr	Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
title_full_unstemmed	Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
title_sort	exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3813632f9e8e4ecba6a67bc9e755093b
work_keys_str_mv	AT yehaoliu exposingtocadmiumstresscauseprofoundtoxiceffectonmicrobiotaofthemiceintestinaltract AT yuhuili exposingtocadmiumstresscauseprofoundtoxiceffectonmicrobiotaofthemiceintestinaltract AT kaiyongliu exposingtocadmiumstresscauseprofoundtoxiceffectonmicrobiotaofthemiceintestinaltract AT jieshen exposingtocadmiumstresscauseprofoundtoxiceffectonmicrobiotaofthemiceintestinaltract
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Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract.

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