Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles

Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda AY Qaid,1 Mohammed Suliman Al-Ayed1 1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection, Department of Physics, Colleg...

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Autores principales:	Abdelhalim MAK, Moussa SAA, Qaid HAY, Al-Ayed MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Antioxidants oxidative stress gold nanoparticles hepatotoxicity vitamin E alpha lipoic acid quercetin arginine melanin rats Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3818a1918ca245f3acd1b37792dd65ef
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spelling	oai:doaj.org-article:3818a1918ca245f3acd1b37792dd65ef2021-12-02T05:39:32ZPotential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles1178-2013https://doaj.org/article/3818a1918ca245f3acd1b37792dd65ef2018-11-01T00:00:00Zhttps://www.dovepress.com/potential-effects-of-different-natural-antioxidants-on-inflammatory-da-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda AY Qaid,1 Mohammed Suliman Al-Ayed1 1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection, Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. A dose of 50 µL of 10 nm GNPs was administered intraperitoneally for 7 days to the rats, whereas the antioxidants were orally administered for the same time period. The antioxidants used in the study were vitamin E (Vit E), α-lipoic acid (ALA), quercetin (Qur), arginine (Arg), and melanin. Forty Wistar-Kyoto male rats were used. Rats were arbitrarily divided into seven groups after acclimatization for 1 week. For serum separation, blood samples were obtained from each animal. Serum liver function markers and tissue oxidative stress and lipid proxidation biomarkers were assessed.Results: The increase in the levels of gamma-glutamyl transferase, alkaline phosphatase, total protein, alanine aminotransferase, and total bilirubin in the serum of rats and the increase of malondialdehyde in the hepatic tissue and decrease in reduced glutathione when compared with the control in this study confirmed the ability of GNPs to cause hazardous effects.Conclusion: Treatment of rats with Vit E, ALA, Qur, Arg, and melanin along with GNPs significantly inhibited the inflammatory liver damage, lipid peroxidation, and the oxidative stress induced by GNPs in vivo, but with different responses due to their evaluated normalization values, and it has been confirmed that melanin is the most powerful antioxidant among these different natural antioxidants, ie, it has the most effective potential role against the hepatic inflammatory damage, oxidative stress, and lipid peroxidation. Keywords: antioxidants, oxidative stress, gold nanoparticles, hepatotoxicity, vitamin E, α-lipoic acid, quercetin, arginine, melanin, ratsAbdelhalim MAKMoussa SAAQaid HAYAl-Ayed MSDove Medical PressarticleAntioxidantsoxidative stressgold nanoparticleshepatotoxicityvitamin Ealpha lipoic acidquercetinargininemelaninratsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7931-7938 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antioxidants oxidative stress gold nanoparticles hepatotoxicity vitamin E alpha lipoic acid quercetin arginine melanin rats Medicine (General) R5-920
spellingShingle	Antioxidants oxidative stress gold nanoparticles hepatotoxicity vitamin E alpha lipoic acid quercetin arginine melanin rats Medicine (General) R5-920 Abdelhalim MAK Moussa SAA Qaid HAY Al-Ayed MS Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
description	Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda AY Qaid,1 Mohammed Suliman Al-Ayed1 1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection, Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. A dose of 50 µL of 10 nm GNPs was administered intraperitoneally for 7 days to the rats, whereas the antioxidants were orally administered for the same time period. The antioxidants used in the study were vitamin E (Vit E), α-lipoic acid (ALA), quercetin (Qur), arginine (Arg), and melanin. Forty Wistar-Kyoto male rats were used. Rats were arbitrarily divided into seven groups after acclimatization for 1 week. For serum separation, blood samples were obtained from each animal. Serum liver function markers and tissue oxidative stress and lipid proxidation biomarkers were assessed.Results: The increase in the levels of gamma-glutamyl transferase, alkaline phosphatase, total protein, alanine aminotransferase, and total bilirubin in the serum of rats and the increase of malondialdehyde in the hepatic tissue and decrease in reduced glutathione when compared with the control in this study confirmed the ability of GNPs to cause hazardous effects.Conclusion: Treatment of rats with Vit E, ALA, Qur, Arg, and melanin along with GNPs significantly inhibited the inflammatory liver damage, lipid peroxidation, and the oxidative stress induced by GNPs in vivo, but with different responses due to their evaluated normalization values, and it has been confirmed that melanin is the most powerful antioxidant among these different natural antioxidants, ie, it has the most effective potential role against the hepatic inflammatory damage, oxidative stress, and lipid peroxidation. Keywords: antioxidants, oxidative stress, gold nanoparticles, hepatotoxicity, vitamin E, α-lipoic acid, quercetin, arginine, melanin, rats
format	article
author	Abdelhalim MAK Moussa SAA Qaid HAY Al-Ayed MS
author_facet	Abdelhalim MAK Moussa SAA Qaid HAY Al-Ayed MS
author_sort	Abdelhalim MAK
title	Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
title_short	Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
title_full	Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
title_fullStr	Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
title_full_unstemmed	Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
title_sort	potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3818a1918ca245f3acd1b37792dd65ef
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_version_	1718400289268039680

Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles

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