Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.

Longitudinal imaging studies are crucial for advancing the understanding of brain development over the lifespan. Thus, more and more studies acquire imaging data at multiple time points or with long follow-up intervals. In these studies changes to magnetic resonance imaging (MRI) scanners often beco...

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Autores principales:	Evelyn Medawar, Ronja Thieleking, Iryna Manuilova, Maria Paerisch, Arno Villringer, A Veronica Witte, Frauke Beyer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38217c09dc044c56b2b01f28de0e3091
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id	oai:doaj.org-article:38217c09dc044c56b2b01f28de0e3091
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spelling	oai:doaj.org-article:38217c09dc044c56b2b01f28de0e30912021-12-02T20:13:50ZEstimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.1932-620310.1371/journal.pone.0239021https://doaj.org/article/38217c09dc044c56b2b01f28de0e30912021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0239021https://doaj.org/toc/1932-6203Longitudinal imaging studies are crucial for advancing the understanding of brain development over the lifespan. Thus, more and more studies acquire imaging data at multiple time points or with long follow-up intervals. In these studies changes to magnetic resonance imaging (MRI) scanners often become inevitable which may decrease the reliability of the MRI assessments and introduce biases. We therefore investigated the difference between MRI scanners with subsequent versions (3 Tesla Siemens Verio vs. Skyra) on the cortical and subcortical measures of grey matter in 116 healthy, young adults using the well-established longitudinal FreeSurfer stream for T1-weighted brain images. We found excellent between-scanner reliability for cortical and subcortical measures of grey matter structure (intra-class correlation coefficient > 0.8). Yet, paired t-tests revealed statistically significant differences in at least 67% of the regions, with percent differences around 2 to 4%, depending on the outcome measure. Offline correction for gradient distortions only slightly reduced these biases. Further, T1-imaging based quality measures reflecting gray-white matter contrast systematically differed between scanners. We conclude that scanner upgrades during a longitudinal study introduce bias in measures of cortical and subcortical grey matter structure. Therefore, before upgrading a MRI scanner during an ongoing study, researchers should prepare to implement an appropriate correction method for these effects.Evelyn MedawarRonja ThielekingIryna ManuilovaMaria PaerischArno VillringerA Veronica WitteFrauke BeyerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0239021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evelyn Medawar Ronja Thieleking Iryna Manuilova Maria Paerisch Arno Villringer A Veronica Witte Frauke Beyer Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
description	Longitudinal imaging studies are crucial for advancing the understanding of brain development over the lifespan. Thus, more and more studies acquire imaging data at multiple time points or with long follow-up intervals. In these studies changes to magnetic resonance imaging (MRI) scanners often become inevitable which may decrease the reliability of the MRI assessments and introduce biases. We therefore investigated the difference between MRI scanners with subsequent versions (3 Tesla Siemens Verio vs. Skyra) on the cortical and subcortical measures of grey matter in 116 healthy, young adults using the well-established longitudinal FreeSurfer stream for T1-weighted brain images. We found excellent between-scanner reliability for cortical and subcortical measures of grey matter structure (intra-class correlation coefficient > 0.8). Yet, paired t-tests revealed statistically significant differences in at least 67% of the regions, with percent differences around 2 to 4%, depending on the outcome measure. Offline correction for gradient distortions only slightly reduced these biases. Further, T1-imaging based quality measures reflecting gray-white matter contrast systematically differed between scanners. We conclude that scanner upgrades during a longitudinal study introduce bias in measures of cortical and subcortical grey matter structure. Therefore, before upgrading a MRI scanner during an ongoing study, researchers should prepare to implement an appropriate correction method for these effects.
format	article
author	Evelyn Medawar Ronja Thieleking Iryna Manuilova Maria Paerisch Arno Villringer A Veronica Witte Frauke Beyer
author_facet	Evelyn Medawar Ronja Thieleking Iryna Manuilova Maria Paerisch Arno Villringer A Veronica Witte Frauke Beyer
author_sort	Evelyn Medawar
title	Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
title_short	Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
title_full	Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
title_fullStr	Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
title_full_unstemmed	Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
title_sort	estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/38217c09dc044c56b2b01f28de0e3091
work_keys_str_mv	AT evelynmedawar estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns AT ronjathieleking estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns AT irynamanuilova estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns AT mariapaerisch estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns AT arnovillringer estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns AT averonicawitte estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns AT fraukebeyer estimatingtheeffectofascannerupgradeonmeasuresofgreymatterstructureforlongitudinaldesigns
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Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.

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