Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mouzarllem B. Reis, Fernanda L. Rodrigues, Natalia Lautherbach, Alexandre Kanashiro, Carlos A. Sorgi, Alyne F. G. Meirelles, Carlos A. A. Silva, Karina F. Zoccal, Camila O. S. Souza, Simone G. Ramos, Alessandra K. Matsuno, Lenaldo B. Rocha, Helio C. Salgado, Luiz C. C. Navegantes, Ísis C. Kettelhut, Palmira Cupo, Luiz G. Gardinassi, Lúcia H. Faccioli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3824a55bb5ce42fc8ddfb1f913df0a2a
record_format	dspace
spelling	oai:doaj.org-article:3824a55bb5ce42fc8ddfb1f913df0a2a2021-12-02T15:39:25ZInterleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation10.1038/s41467-020-19232-82041-1723https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19232-8https://doaj.org/toc/2041-1723Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.Mouzarllem B. ReisFernanda L. RodriguesNatalia LautherbachAlexandre KanashiroCarlos A. SorgiAlyne F. G. MeirellesCarlos A. A. SilvaKarina F. ZoccalCamila O. S. SouzaSimone G. RamosAlessandra K. MatsunoLenaldo B. RochaHelio C. SalgadoLuiz C. C. NavegantesÍsis C. KettelhutPalmira CupoLuiz G. GardinassiLúcia H. FaccioliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mouzarllem B. Reis Fernanda L. Rodrigues Natalia Lautherbach Alexandre Kanashiro Carlos A. Sorgi Alyne F. G. Meirelles Carlos A. A. Silva Karina F. Zoccal Camila O. S. Souza Simone G. Ramos Alessandra K. Matsuno Lenaldo B. Rocha Helio C. Salgado Luiz C. C. Navegantes Ísis C. Kettelhut Palmira Cupo Luiz G. Gardinassi Lúcia H. Faccioli Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
description	Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
format	article
author	Mouzarllem B. Reis Fernanda L. Rodrigues Natalia Lautherbach Alexandre Kanashiro Carlos A. Sorgi Alyne F. G. Meirelles Carlos A. A. Silva Karina F. Zoccal Camila O. S. Souza Simone G. Ramos Alessandra K. Matsuno Lenaldo B. Rocha Helio C. Salgado Luiz C. C. Navegantes Ísis C. Kettelhut Palmira Cupo Luiz G. Gardinassi Lúcia H. Faccioli
author_facet	Mouzarllem B. Reis Fernanda L. Rodrigues Natalia Lautherbach Alexandre Kanashiro Carlos A. Sorgi Alyne F. G. Meirelles Carlos A. A. Silva Karina F. Zoccal Camila O. S. Souza Simone G. Ramos Alessandra K. Matsuno Lenaldo B. Rocha Helio C. Salgado Luiz C. C. Navegantes Ísis C. Kettelhut Palmira Cupo Luiz G. Gardinassi Lúcia H. Faccioli
author_sort	Mouzarllem B. Reis
title	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_short	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_full	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_fullStr	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_full_unstemmed	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_sort	interleukin-1 receptor-induced pge2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a
work_keys_str_mv	AT mouzarllembreis interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT fernandalrodrigues interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT natalialautherbach interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT alexandrekanashiro interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT carlosasorgi interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT alynefgmeirelles interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT carlosaasilva interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT karinafzoccal interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT camilaossouza interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT simonegramos interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT alessandrakmatsuno interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT lenaldobrocha interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT heliocsalgado interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT luizccnavegantes interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT isisckettelhut interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT palmiracupo interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT luizggardinassi interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation AT luciahfaccioli interleukin1receptorinducedpge2productioncontrolsacetylcholinemediatedcardiacdysfunctionandmortalityduringscorpionenvenomation
_version_	1718385926309150720

Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

Ejemplares similares