Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunc...

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Auteurs principaux:	Mouzarllem B. Reis, Fernanda L. Rodrigues, Natalia Lautherbach, Alexandre Kanashiro, Carlos A. Sorgi, Alyne F. G. Meirelles, Carlos A. A. Silva, Karina F. Zoccal, Camila O. S. Souza, Simone G. Ramos, Alessandra K. Matsuno, Lenaldo B. Rocha, Helio C. Salgado, Luiz C. C. Navegantes, Ísis C. Kettelhut, Palmira Cupo, Luiz G. Gardinassi, Lúcia H. Faccioli
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a
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spelling	oai:doaj.org-article:3824a55bb5ce42fc8ddfb1f913df0a2a2021-12-02T15:39:25ZInterleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation10.1038/s41467-020-19232-82041-1723https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19232-8https://doaj.org/toc/2041-1723Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.Mouzarllem B. ReisFernanda L. RodriguesNatalia LautherbachAlexandre KanashiroCarlos A. SorgiAlyne F. G. MeirellesCarlos A. A. SilvaKarina F. ZoccalCamila O. S. SouzaSimone G. RamosAlessandra K. MatsunoLenaldo B. RochaHelio C. SalgadoLuiz C. C. NavegantesÍsis C. KettelhutPalmira CupoLuiz G. GardinassiLúcia H. FaccioliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mouzarllem B. Reis Fernanda L. Rodrigues Natalia Lautherbach Alexandre Kanashiro Carlos A. Sorgi Alyne F. G. Meirelles Carlos A. A. Silva Karina F. Zoccal Camila O. S. Souza Simone G. Ramos Alessandra K. Matsuno Lenaldo B. Rocha Helio C. Salgado Luiz C. C. Navegantes Ísis C. Kettelhut Palmira Cupo Luiz G. Gardinassi Lúcia H. Faccioli Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
description	Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
format	article
author	Mouzarllem B. Reis Fernanda L. Rodrigues Natalia Lautherbach Alexandre Kanashiro Carlos A. Sorgi Alyne F. G. Meirelles Carlos A. A. Silva Karina F. Zoccal Camila O. S. Souza Simone G. Ramos Alessandra K. Matsuno Lenaldo B. Rocha Helio C. Salgado Luiz C. C. Navegantes Ísis C. Kettelhut Palmira Cupo Luiz G. Gardinassi Lúcia H. Faccioli
author_facet	Mouzarllem B. Reis Fernanda L. Rodrigues Natalia Lautherbach Alexandre Kanashiro Carlos A. Sorgi Alyne F. G. Meirelles Carlos A. A. Silva Karina F. Zoccal Camila O. S. Souza Simone G. Ramos Alessandra K. Matsuno Lenaldo B. Rocha Helio C. Salgado Luiz C. C. Navegantes Ísis C. Kettelhut Palmira Cupo Luiz G. Gardinassi Lúcia H. Faccioli
author_sort	Mouzarllem B. Reis
title	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_short	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_full	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_fullStr	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_full_unstemmed	Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
title_sort	interleukin-1 receptor-induced pge2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a
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Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

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