Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer

Summary: Background: The CDC and WHO recommend alcohol-based hand sanitizers to inactivate severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]. Aim: Benzalkonium chloride [BAK] is another hand sanitizer active ingredient that could be used in response to the global pandemic. Deployment of...

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Autores principales:	Brandon L. Herdt, Elaine P. Black, Sifang S. Zhou, Cameron J. Wilde
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Benzalkonium chloride [BAK] SARS-CoV-2 Hand hygiene Sanitizer Alcohol Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/382c7a97766b485b85ed51d864b9220e
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spelling	oai:doaj.org-article:382c7a97766b485b85ed51d864b9220e2021-12-04T04:35:46ZInactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer2590-088910.1016/j.infpip.2021.100191https://doaj.org/article/382c7a97766b485b85ed51d864b9220e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590088921000809https://doaj.org/toc/2590-0889Summary: Background: The CDC and WHO recommend alcohol-based hand sanitizers to inactivate severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]. Aim: Benzalkonium chloride [BAK] is another hand sanitizer active ingredient that could be used in response to the global pandemic. Deployment of BAK-based hand sanitizers could reduce shortages of alcohol products and increase hand hygiene options where there are social, physical, and toxicological constraints on alcohol use. Methods: Two commercially available BAK-based hand sanitizers, a concentrate diluted on-site with water and a ready-to-use product, were tested for activity against SARS-CoV-2 in the European Norm Virucidal Activity Suspension Test [EN14476]. A WHO and CDC-recommended 80% alcohol-based hand sanitizer formulation was tested in parallel. Findings: Both BAK formulations demonstrated a ≥4.0 log10 reduction of SARS-CoV-2 in 30 seconds, meeting the EN14476 performance standard for virucidal activity against SARS-CoV-2 and matching the in vitro effectiveness of the ethanol-based sanitizer. Conclusion: These findings indicate that a commercial BAK hand hygiene formulation may be another effective means of inactivating the SARS-CoV-2 virus and could be considered as option for pandemic response.Brandon L. HerdtElaine P. BlackSifang S. ZhouCameron J. WildeElsevierarticleBenzalkonium chloride [BAK]SARS-CoV-2Hand hygieneSanitizerAlcoholInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENInfection Prevention in Practice, Vol 3, Iss 4, Pp 100191- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Benzalkonium chloride [BAK] SARS-CoV-2 Hand hygiene Sanitizer Alcohol Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Benzalkonium chloride [BAK] SARS-CoV-2 Hand hygiene Sanitizer Alcohol Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Brandon L. Herdt Elaine P. Black Sifang S. Zhou Cameron J. Wilde Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
description	Summary: Background: The CDC and WHO recommend alcohol-based hand sanitizers to inactivate severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]. Aim: Benzalkonium chloride [BAK] is another hand sanitizer active ingredient that could be used in response to the global pandemic. Deployment of BAK-based hand sanitizers could reduce shortages of alcohol products and increase hand hygiene options where there are social, physical, and toxicological constraints on alcohol use. Methods: Two commercially available BAK-based hand sanitizers, a concentrate diluted on-site with water and a ready-to-use product, were tested for activity against SARS-CoV-2 in the European Norm Virucidal Activity Suspension Test [EN14476]. A WHO and CDC-recommended 80% alcohol-based hand sanitizer formulation was tested in parallel. Findings: Both BAK formulations demonstrated a ≥4.0 log10 reduction of SARS-CoV-2 in 30 seconds, meeting the EN14476 performance standard for virucidal activity against SARS-CoV-2 and matching the in vitro effectiveness of the ethanol-based sanitizer. Conclusion: These findings indicate that a commercial BAK hand hygiene formulation may be another effective means of inactivating the SARS-CoV-2 virus and could be considered as option for pandemic response.
format	article
author	Brandon L. Herdt Elaine P. Black Sifang S. Zhou Cameron J. Wilde
author_facet	Brandon L. Herdt Elaine P. Black Sifang S. Zhou Cameron J. Wilde
author_sort	Brandon L. Herdt
title	Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
title_short	Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
title_full	Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
title_fullStr	Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
title_full_unstemmed	Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
title_sort	inactivation of sars-cov-2 by 2 commercially available benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/382c7a97766b485b85ed51d864b9220e
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Inactivation of SARS-CoV-2 by 2 commercially available Benzalkonium chloride-based hand sanitizers in comparison with an 80% ethanol-based hand sanitizer

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