Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer

Despite the increasing urgency of the problem of treating small cell lung cancer (SCLC), information on the causes of its development is fragmentary. There is no complete understanding of the features of antitumor immunity and the role of the microenvironment in the development of SCLC resistance. T...

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Autores principales:	Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Natalia Ermakova, Edgar Pan, Angelina Pakhomova, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	small cell lung cancer COPD cancer stem cell inflammation CART therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/382cba3cb52546d5881997b33fd66992
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spelling	oai:doaj.org-article:382cba3cb52546d5881997b33fd669922021-12-03T07:20:37ZPotential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer2296-634X10.3389/fcell.2021.778020https://doaj.org/article/382cba3cb52546d5881997b33fd669922021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.778020/fullhttps://doaj.org/toc/2296-634XDespite the increasing urgency of the problem of treating small cell lung cancer (SCLC), information on the causes of its development is fragmentary. There is no complete understanding of the features of antitumor immunity and the role of the microenvironment in the development of SCLC resistance. This impedes the development of new methods for the diagnosis and treatment of SCLC. Lung cancer and chronic obstructive pulmonary disease (COPD) have common pathogenetic factors. COPD is a risk factor for lung cancer including SCLC. Therefore, the search for effective approaches to prevention, diagnosis, and treatment of SCLC in patients with COPD is an urgent task. This review provides information on the etiology and pathogenesis of SCLC, analyses the effectiveness of current treatment options, and critically evaluates the potential of chimeric antigen receptor T cells therapy (CART therapy) in SCLC. Moreover, we discuss potential links between lung cancer and COPD and the role of endothelium in the development of COPD. Finally, we propose a new approach for increasing the efficacy of CART therapy in SCLC.Evgenii SkurikhinOlga PershinaMariia ZhukovaDarius WideraNatalia ErmakovaEdgar PanAngelina PakhomovaSergey MorozovAslan KubatievAlexander DygaiAlexander DygaiFrontiers Media S.A.articlesmall cell lung cancerCOPDcancer stem cellinflammationCART therapyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	small cell lung cancer COPD cancer stem cell inflammation CART therapy Biology (General) QH301-705.5
spellingShingle	small cell lung cancer COPD cancer stem cell inflammation CART therapy Biology (General) QH301-705.5 Evgenii Skurikhin Olga Pershina Mariia Zhukova Darius Widera Natalia Ermakova Edgar Pan Angelina Pakhomova Sergey Morozov Aslan Kubatiev Alexander Dygai Alexander Dygai Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
description	Despite the increasing urgency of the problem of treating small cell lung cancer (SCLC), information on the causes of its development is fragmentary. There is no complete understanding of the features of antitumor immunity and the role of the microenvironment in the development of SCLC resistance. This impedes the development of new methods for the diagnosis and treatment of SCLC. Lung cancer and chronic obstructive pulmonary disease (COPD) have common pathogenetic factors. COPD is a risk factor for lung cancer including SCLC. Therefore, the search for effective approaches to prevention, diagnosis, and treatment of SCLC in patients with COPD is an urgent task. This review provides information on the etiology and pathogenesis of SCLC, analyses the effectiveness of current treatment options, and critically evaluates the potential of chimeric antigen receptor T cells therapy (CART therapy) in SCLC. Moreover, we discuss potential links between lung cancer and COPD and the role of endothelium in the development of COPD. Finally, we propose a new approach for increasing the efficacy of CART therapy in SCLC.
format	article
author	Evgenii Skurikhin Olga Pershina Mariia Zhukova Darius Widera Natalia Ermakova Edgar Pan Angelina Pakhomova Sergey Morozov Aslan Kubatiev Alexander Dygai Alexander Dygai
author_facet	Evgenii Skurikhin Olga Pershina Mariia Zhukova Darius Widera Natalia Ermakova Edgar Pan Angelina Pakhomova Sergey Morozov Aslan Kubatiev Alexander Dygai Alexander Dygai
author_sort	Evgenii Skurikhin
title	Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
title_short	Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
title_full	Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
title_fullStr	Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
title_full_unstemmed	Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer
title_sort	potential of stem cells and cart as a potential polytherapy for small cell lung cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/382cba3cb52546d5881997b33fd66992
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Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer

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