Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction.

Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction.

Epidermal growth factor receptor (EGFR) is a novel target for therapy in subsets of non-small cell lung cancer, especially adenocarcinoma. Tumors with EGFR mutations showed good response to EGFR tyrosine kinase inhibitors (TKIs). We aimed to identify the discriminating capacity of immunohistochemica...

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Autores principales: Shang-Gin Wu, Yih-Leong Chang, Jou-Wei Lin, Chen-Tu Wu, Hsuan-Yu Chen, Meng-Feng Tsai, Yung-Chie Lee, Chong-Jen Yu, Jin-Yuan Shih
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/38319c28a16449babc47690816ee48f6
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