Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II,...

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Autores principales:	Allison Sang, Thomas Danhorn, Jacob N. Peterson, Andrew L. Rankin, Brian P. O’Connor, Sonia M. Leach, Raul M. Torres, Roberta Pelanda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3831f5ead99142fe96cd47ae62a202ba
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spelling	oai:doaj.org-article:3831f5ead99142fe96cd47ae62a202ba2021-12-02T16:49:33ZInnate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus10.1038/s41467-018-06293-z2041-1723https://doaj.org/article/3831f5ead99142fe96cd47ae62a202ba2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06293-zhttps://doaj.org/toc/2041-1723Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II, depend on IL-21 for expansion, and mount stronger memory response.Allison SangThomas DanhornJacob N. PetersonAndrew L. RankinBrian P. O’ConnorSonia M. LeachRaul M. TorresRoberta PelandaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Allison Sang Thomas Danhorn Jacob N. Peterson Andrew L. Rankin Brian P. O’Connor Sonia M. Leach Raul M. Torres Roberta Pelanda Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
description	Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II, depend on IL-21 for expansion, and mount stronger memory response.
format	article
author	Allison Sang Thomas Danhorn Jacob N. Peterson Andrew L. Rankin Brian P. O’Connor Sonia M. Leach Raul M. Torres Roberta Pelanda
author_facet	Allison Sang Thomas Danhorn Jacob N. Peterson Andrew L. Rankin Brian P. O’Connor Sonia M. Leach Raul M. Torres Roberta Pelanda
author_sort	Allison Sang
title	Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
title_short	Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
title_full	Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
title_fullStr	Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
title_full_unstemmed	Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
title_sort	innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive b cells in lupus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3831f5ead99142fe96cd47ae62a202ba
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Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

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