Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missense point mutation in NLRP12 that is associated wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler, Kathleen A. M. Mills, Ann M. Janowski, A. Paige Davis Volk, Kai Wang, Kevin L. Legge, Lokesh Gakhar, Mohammed Bourdi, Polly J. Ferguson, Mary E. Wilson, Suzanne L. Cassel, Fayyaz S. Sutterwala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:383567b1d23c49cca2e3d2f968f86070
record_format	dspace
spelling	oai:doaj.org-article:383567b1d23c49cca2e3d2f968f860702021-12-02T16:49:41ZNlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment10.1038/ncomms131802041-1723https://doaj.org/article/383567b1d23c49cca2e3d2f968f860702016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13180https://doaj.org/toc/2041-1723The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missense point mutation in NLRP12 that is associated with defective neutrophil recruitment.Tyler K. UllandNidhi JainEmma E. HornickEric I. ElliottGwendolyn M. ClayJeffrey J. SadlerKathleen A. M. MillsAnn M. JanowskiA. Paige Davis VolkKai WangKevin L. LeggeLokesh GakharMohammed BourdiPolly J. FergusonMary E. WilsonSuzanne L. CasselFayyaz S. SutterwalaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tyler K. Ulland Nidhi Jain Emma E. Hornick Eric I. Elliott Gwendolyn M. Clay Jeffrey J. Sadler Kathleen A. M. Mills Ann M. Janowski A. Paige Davis Volk Kai Wang Kevin L. Legge Lokesh Gakhar Mohammed Bourdi Polly J. Ferguson Mary E. Wilson Suzanne L. Cassel Fayyaz S. Sutterwala Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
description	The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missense point mutation in NLRP12 that is associated with defective neutrophil recruitment.
format	article
author	Tyler K. Ulland Nidhi Jain Emma E. Hornick Eric I. Elliott Gwendolyn M. Clay Jeffrey J. Sadler Kathleen A. M. Mills Ann M. Janowski A. Paige Davis Volk Kai Wang Kevin L. Legge Lokesh Gakhar Mohammed Bourdi Polly J. Ferguson Mary E. Wilson Suzanne L. Cassel Fayyaz S. Sutterwala
author_facet	Tyler K. Ulland Nidhi Jain Emma E. Hornick Eric I. Elliott Gwendolyn M. Clay Jeffrey J. Sadler Kathleen A. M. Mills Ann M. Janowski A. Paige Davis Volk Kai Wang Kevin L. Legge Lokesh Gakhar Mohammed Bourdi Polly J. Ferguson Mary E. Wilson Suzanne L. Cassel Fayyaz S. Sutterwala
author_sort	Tyler K. Ulland
title	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
title_short	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
title_full	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
title_fullStr	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
title_full_unstemmed	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
title_sort	nlrp12 mutation causes c57bl/6j strain-specific defect in neutrophil recruitment
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
work_keys_str_mv	AT tylerkulland nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT nidhijain nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT emmaehornick nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT ericielliott nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT gwendolynmclay nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT jeffreyjsadler nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT kathleenammills nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT annmjanowski nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT apaigedavisvolk nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT kaiwang nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT kevinllegge nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT lokeshgakhar nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT mohammedbourdi nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT pollyjferguson nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT maryewilson nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT suzannelcassel nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment AT fayyazssutterwala nlrp12mutationcausesc57bl6jstrainspecificdefectinneutrophilrecruitment
_version_	1718383208883552256

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

Ejemplares similares