Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei

Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei

Abstract Trypanosoma brucei is a unicellular parasite responsible for African trypanosomiasis or sleeping sickness. It contains a single PARP enzyme opposed to many higher eukaryotes, which have numerous PARPs. PARPs are responsible for a post-translational modification, ADP-ribosylation, regulating...

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Autores principales: Teemu Haikarainen, Mariana Schlesinger, Ezeogo Obaji, Silvia H. Fernández Villamil, Lari Lehtiö
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/383567bfb60a4e1f9f36829cf9b4a8ca
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