Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy

Background: The use of non-steroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy can cause premature constriction of the ductus arteriosus. This report describes a case of in utero narrowing of the ductus arteriosus (DA) diagnosed postnatally in a baby with Persistent Pu...

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Autores principales:	Kévin Le Duc, Sixtine Gilliot, Jean Benoit Baudelet, Sébastien Mur, Mohamed Riadh Boukhris, Olivia Domanski, Pascal Odou, Laurent Storme
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PPHN (persistent pulmonary hypertension of the newborn) NSAID (non-steroidal anti-inflammatory drug) ductus arteriosus NICU (neonatal intensive care unit) pregnancy neonate Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3837d8aeb41940909e72a7af8ee8a76a
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spelling	oai:doaj.org-article:3837d8aeb41940909e72a7af8ee8a76a2021-11-30T23:39:49ZCase Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy1663-981210.3389/fphar.2021.756056https://doaj.org/article/3837d8aeb41940909e72a7af8ee8a76a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.756056/fullhttps://doaj.org/toc/1663-9812Background: The use of non-steroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy can cause premature constriction of the ductus arteriosus. This report describes a case of in utero narrowing of the ductus arteriosus (DA) diagnosed postnatally in a baby with Persistent Pulmonary Hypertension of the Newborn (PPHN), after maternal use of Diclofenac-Epolamine 140 mg patch during the second and third trimester.Case Presentation: A fetal ultrasounds revealed an enlarged hypertrophic right ventricle at 32 weeks of gestation. Detailed questioning of the mother highlighted that topical Diclofenac (FLECTOR®) had been used at 26 and at 31 weeks of gestation. An echocardiography performed 8 h postnatally showed supra-systemic pulmonary hypertension, a restrictive ductus arteriosus and a dilated right ventricle. The newborn was treated by inhaled nitric oxide and oral Sildenafil and was discharged from hospital on day 24. He had a complete normalization of his pulmonary vascular resistance on day 48.Conclusion: This case illustrates the potential fetal and neonatal complications associated with maternal topical Diclofenac medication during pregnancy resulting in antenatal closure of the DA.Kévin Le DucKévin Le DucSixtine GilliotSixtine GilliotJean Benoit BaudeletSébastien MurMohamed Riadh BoukhrisOlivia DomanskiPascal OdouPascal OdouLaurent StormeLaurent StormeFrontiers Media S.A.articlePPHN (persistent pulmonary hypertension of the newborn)NSAID (non-steroidal anti-inflammatory drug)ductus arteriosusNICU (neonatal intensive care unit)pregnancyneonateTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PPHN (persistent pulmonary hypertension of the newborn) NSAID (non-steroidal anti-inflammatory drug) ductus arteriosus NICU (neonatal intensive care unit) pregnancy neonate Therapeutics. Pharmacology RM1-950
spellingShingle	PPHN (persistent pulmonary hypertension of the newborn) NSAID (non-steroidal anti-inflammatory drug) ductus arteriosus NICU (neonatal intensive care unit) pregnancy neonate Therapeutics. Pharmacology RM1-950 Kévin Le Duc Kévin Le Duc Sixtine Gilliot Sixtine Gilliot Jean Benoit Baudelet Sébastien Mur Mohamed Riadh Boukhris Olivia Domanski Pascal Odou Pascal Odou Laurent Storme Laurent Storme Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy
description	Background: The use of non-steroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy can cause premature constriction of the ductus arteriosus. This report describes a case of in utero narrowing of the ductus arteriosus (DA) diagnosed postnatally in a baby with Persistent Pulmonary Hypertension of the Newborn (PPHN), after maternal use of Diclofenac-Epolamine 140 mg patch during the second and third trimester.Case Presentation: A fetal ultrasounds revealed an enlarged hypertrophic right ventricle at 32 weeks of gestation. Detailed questioning of the mother highlighted that topical Diclofenac (FLECTOR®) had been used at 26 and at 31 weeks of gestation. An echocardiography performed 8 h postnatally showed supra-systemic pulmonary hypertension, a restrictive ductus arteriosus and a dilated right ventricle. The newborn was treated by inhaled nitric oxide and oral Sildenafil and was discharged from hospital on day 24. He had a complete normalization of his pulmonary vascular resistance on day 48.Conclusion: This case illustrates the potential fetal and neonatal complications associated with maternal topical Diclofenac medication during pregnancy resulting in antenatal closure of the DA.
format	article
author	Kévin Le Duc Kévin Le Duc Sixtine Gilliot Sixtine Gilliot Jean Benoit Baudelet Sébastien Mur Mohamed Riadh Boukhris Olivia Domanski Pascal Odou Pascal Odou Laurent Storme Laurent Storme
author_facet	Kévin Le Duc Kévin Le Duc Sixtine Gilliot Sixtine Gilliot Jean Benoit Baudelet Sébastien Mur Mohamed Riadh Boukhris Olivia Domanski Pascal Odou Pascal Odou Laurent Storme Laurent Storme
author_sort	Kévin Le Duc
title	Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy
title_short	Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy
title_full	Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy
title_fullStr	Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy
title_full_unstemmed	Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy
title_sort	case report: persistent pulmonary hypertension of the newborn and narrowing of the ductus arteriosus after topical use of non-steroidal anti-inflammatory during pregnancy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3837d8aeb41940909e72a7af8ee8a76a
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Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy

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