VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

The Rho signalling pathway is frequently activated in squamous carcinomas. Here, the authors find that the Rho GEF VAV2 is over expressed in both cutaneous and head and neck squamous cell carcinomas and that at the molecular level VAV2 promotes a pro-tumorigenic stem cell-like signalling programme.

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Autores principales:	L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, Sonia Rodríguez-Fdez, Javier Robles-Valero, Sonia Zumalave, Salvatore Fabbiano, Gloria Pascual, Juana M. García-Pedrero, Antonio Abad, María C. García-Macías, Nazareno González, Pablo Lorenzano-Menna, Miguel A. Pavón, Rogelio González-Sarmiento, Carmen Segrelles, Jesús M. Paramio, José M. C. Tubío, Juan P. Rodrigo, Salvador A. Benitah, Myriam Cuadrado, Xosé R. Bustelo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c
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spelling	oai:doaj.org-article:383992e6d52c41ef94a9df8bb7b4e08c2021-12-02T15:14:48ZVAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma10.1038/s41467-020-18524-32041-1723https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18524-3https://doaj.org/toc/2041-1723The Rho signalling pathway is frequently activated in squamous carcinomas. Here, the authors find that the Rho GEF VAV2 is over expressed in both cutaneous and head and neck squamous cell carcinomas and that at the molecular level VAV2 promotes a pro-tumorigenic stem cell-like signalling programme.L. Francisco Lorenzo-MartínNatalia Fernández-ParejoMauricio Menacho-MárquezSonia Rodríguez-FdezJavier Robles-ValeroSonia ZumalaveSalvatore FabbianoGloria PascualJuana M. García-PedreroAntonio AbadMaría C. García-MacíasNazareno GonzálezPablo Lorenzano-MennaMiguel A. PavónRogelio González-SarmientoCarmen SegrellesJesús M. ParamioJosé M. C. TubíoJuan P. RodrigoSalvador A. BenitahMyriam CuadradoXosé R. BusteloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q L. Francisco Lorenzo-Martín Natalia Fernández-Parejo Mauricio Menacho-Márquez Sonia Rodríguez-Fdez Javier Robles-Valero Sonia Zumalave Salvatore Fabbiano Gloria Pascual Juana M. García-Pedrero Antonio Abad María C. García-Macías Nazareno González Pablo Lorenzano-Menna Miguel A. Pavón Rogelio González-Sarmiento Carmen Segrelles Jesús M. Paramio José M. C. Tubío Juan P. Rodrigo Salvador A. Benitah Myriam Cuadrado Xosé R. Bustelo VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
description	The Rho signalling pathway is frequently activated in squamous carcinomas. Here, the authors find that the Rho GEF VAV2 is over expressed in both cutaneous and head and neck squamous cell carcinomas and that at the molecular level VAV2 promotes a pro-tumorigenic stem cell-like signalling programme.
format	article
author	L. Francisco Lorenzo-Martín Natalia Fernández-Parejo Mauricio Menacho-Márquez Sonia Rodríguez-Fdez Javier Robles-Valero Sonia Zumalave Salvatore Fabbiano Gloria Pascual Juana M. García-Pedrero Antonio Abad María C. García-Macías Nazareno González Pablo Lorenzano-Menna Miguel A. Pavón Rogelio González-Sarmiento Carmen Segrelles Jesús M. Paramio José M. C. Tubío Juan P. Rodrigo Salvador A. Benitah Myriam Cuadrado Xosé R. Bustelo
author_facet	L. Francisco Lorenzo-Martín Natalia Fernández-Parejo Mauricio Menacho-Márquez Sonia Rodríguez-Fdez Javier Robles-Valero Sonia Zumalave Salvatore Fabbiano Gloria Pascual Juana M. García-Pedrero Antonio Abad María C. García-Macías Nazareno González Pablo Lorenzano-Menna Miguel A. Pavón Rogelio González-Sarmiento Carmen Segrelles Jesús M. Paramio José M. C. Tubío Juan P. Rodrigo Salvador A. Benitah Myriam Cuadrado Xosé R. Bustelo
author_sort	L. Francisco Lorenzo-Martín
title	VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
title_short	VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
title_full	VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
title_fullStr	VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
title_full_unstemmed	VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
title_sort	vav2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c
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VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

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