VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

The Rho signalling pathway is frequently activated in squamous carcinomas. Here, the authors find that the Rho GEF VAV2 is over expressed in both cutaneous and head and neck squamous cell carcinomas and that at the molecular level VAV2 promotes a pro-tumorigenic stem cell-like signalling programme.

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Bibliographic Details
Main Authors: L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, Sonia Rodríguez-Fdez, Javier Robles-Valero, Sonia Zumalave, Salvatore Fabbiano, Gloria Pascual, Juana M. García-Pedrero, Antonio Abad, María C. García-Macías, Nazareno González, Pablo Lorenzano-Menna, Miguel A. Pavón, Rogelio González-Sarmiento, Carmen Segrelles, Jesús M. Paramio, José M. C. Tubío, Juan P. Rodrigo, Salvador A. Benitah, Myriam Cuadrado, Xosé R. Bustelo
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c
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