Clinical effects of cervical conization with positive margins in cervical cancer

Abstract Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to i...

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Autores principales:	Yukari Nagao, Akira Yokoi, Kosuke Yoshida, Masanori Sumi, Masato Yoshihara, Satoshi Tamauchi, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kimihiro Nishino, Kaoru Niimi, Hiroaki Kajiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/383a8d981b1d4f2895b5a48bf019e6e0
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spelling	oai:doaj.org-article:383a8d981b1d4f2895b5a48bf019e6e02021-12-05T12:15:48ZClinical effects of cervical conization with positive margins in cervical cancer10.1038/s41598-021-02635-y2045-2322https://doaj.org/article/383a8d981b1d4f2895b5a48bf019e6e02021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02635-yhttps://doaj.org/toc/2045-2322Abstract Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigate the clinical outcomes of positive margins at conization in cervical cancer. A total of 101 patients who underwent cervical conization before radical hysterectomy and pelvic lymph node dissection were considered eligible by reviewing medical records. The association between the positive margins and patient outcomes, including subsequent lymph node metastasis, was evaluated. The rate of lymphovascular space invasion (LVSI) positivity at radical surgery was significantly higher in patients with positive margins (p = 0.017) than in those with negative margins, although there was no significant difference in the rate of pelvic lymph node metastasis (p = 0.155). Moreover, there was no significant difference in the overall survival or progression-free survival between the two groups (p = 0.332 and 0.200, respectively). A positive margin at conization presented no significant prognostic disadvantage; thus, diagnostic conization is one of the most suitable treatment options for early-stage cervical cancer that is difficult to accurately assess.Yukari NagaoAkira YokoiKosuke YoshidaMasanori SumiMasato YoshiharaSatoshi TamauchiYoshiki IkedaNobuhisa YoshikawaKimihiro NishinoKaoru NiimiHiroaki KajiyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukari Nagao Akira Yokoi Kosuke Yoshida Masanori Sumi Masato Yoshihara Satoshi Tamauchi Yoshiki Ikeda Nobuhisa Yoshikawa Kimihiro Nishino Kaoru Niimi Hiroaki Kajiyama Clinical effects of cervical conization with positive margins in cervical cancer
description	Abstract Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigate the clinical outcomes of positive margins at conization in cervical cancer. A total of 101 patients who underwent cervical conization before radical hysterectomy and pelvic lymph node dissection were considered eligible by reviewing medical records. The association between the positive margins and patient outcomes, including subsequent lymph node metastasis, was evaluated. The rate of lymphovascular space invasion (LVSI) positivity at radical surgery was significantly higher in patients with positive margins (p = 0.017) than in those with negative margins, although there was no significant difference in the rate of pelvic lymph node metastasis (p = 0.155). Moreover, there was no significant difference in the overall survival or progression-free survival between the two groups (p = 0.332 and 0.200, respectively). A positive margin at conization presented no significant prognostic disadvantage; thus, diagnostic conization is one of the most suitable treatment options for early-stage cervical cancer that is difficult to accurately assess.
format	article
author	Yukari Nagao Akira Yokoi Kosuke Yoshida Masanori Sumi Masato Yoshihara Satoshi Tamauchi Yoshiki Ikeda Nobuhisa Yoshikawa Kimihiro Nishino Kaoru Niimi Hiroaki Kajiyama
author_facet	Yukari Nagao Akira Yokoi Kosuke Yoshida Masanori Sumi Masato Yoshihara Satoshi Tamauchi Yoshiki Ikeda Nobuhisa Yoshikawa Kimihiro Nishino Kaoru Niimi Hiroaki Kajiyama
author_sort	Yukari Nagao
title	Clinical effects of cervical conization with positive margins in cervical cancer
title_short	Clinical effects of cervical conization with positive margins in cervical cancer
title_full	Clinical effects of cervical conization with positive margins in cervical cancer
title_fullStr	Clinical effects of cervical conization with positive margins in cervical cancer
title_full_unstemmed	Clinical effects of cervical conization with positive margins in cervical cancer
title_sort	clinical effects of cervical conization with positive margins in cervical cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/383a8d981b1d4f2895b5a48bf019e6e0
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Clinical effects of cervical conization with positive margins in cervical cancer

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