Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report

Abstract Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty aci...

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Autores principales:	Amritpal S. Bhullar, Irma Magaly Rivas-Serna, Ana Anoveros-Barrera, Abha Dunichand-Hoedl, David Bigam, Rachel G. Khadaroo, Todd McMullen, Oliver Bathe, Charles T. Putman, Vickie Baracos, Michael T. Clandinin, Vera C. Mazurak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/383b0da5f06f447e92053de802692a2e
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spelling	oai:doaj.org-article:383b0da5f06f447e92053de802692a2e2021-11-28T12:19:51ZDepletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report10.1038/s41598-021-02269-02045-2322https://doaj.org/article/383b0da5f06f447e92053de802692a2e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02269-0https://doaj.org/toc/2045-2322Abstract Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720–800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11–10.87), p = 0.03], EPA [HR 3.92 (1.1–14.0), p = 0.04] and DHA [HR 4.08 (1.1–14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer.Amritpal S. BhullarIrma Magaly Rivas-SernaAna Anoveros-BarreraAbha Dunichand-HoedlDavid BigamRachel G. KhadarooTodd McMullenOliver BatheCharles T. PutmanVickie BaracosMichael T. ClandininVera C. MazurakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amritpal S. Bhullar Irma Magaly Rivas-Serna Ana Anoveros-Barrera Abha Dunichand-Hoedl David Bigam Rachel G. Khadaroo Todd McMullen Oliver Bathe Charles T. Putman Vickie Baracos Michael T. Clandinin Vera C. Mazurak Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
description	Abstract Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720–800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11–10.87), p = 0.03], EPA [HR 3.92 (1.1–14.0), p = 0.04] and DHA [HR 4.08 (1.1–14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer.
format	article
author	Amritpal S. Bhullar Irma Magaly Rivas-Serna Ana Anoveros-Barrera Abha Dunichand-Hoedl David Bigam Rachel G. Khadaroo Todd McMullen Oliver Bathe Charles T. Putman Vickie Baracos Michael T. Clandinin Vera C. Mazurak
author_facet	Amritpal S. Bhullar Irma Magaly Rivas-Serna Ana Anoveros-Barrera Abha Dunichand-Hoedl David Bigam Rachel G. Khadaroo Todd McMullen Oliver Bathe Charles T. Putman Vickie Baracos Michael T. Clandinin Vera C. Mazurak
author_sort	Amritpal S. Bhullar
title	Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
title_short	Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
title_full	Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
title_fullStr	Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
title_full_unstemmed	Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
title_sort	depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/383b0da5f06f447e92053de802692a2e
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Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report

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