Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct re...

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Autores principales:	Brice Lagrange, Sacha Benaoudia, Pierre Wallet, Flora Magnotti, Angelina Provost, Fanny Michal, Amandine Martin, Flaviana Di Lorenzo, Bénédicte F. Py, Antonio Molinaro, Thomas Henry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/383b81a68c0640c08b987c32fdbd2fe2
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spelling	oai:doaj.org-article:383b81a68c0640c08b987c32fdbd2fe22021-12-02T14:39:07ZHuman caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-1110.1038/s41467-017-02682-y2041-1723https://doaj.org/article/383b81a68c0640c08b987c32fdbd2fe22018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02682-yhttps://doaj.org/toc/2041-1723Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct recognition of under-acylated lipid A.Brice LagrangeSacha BenaoudiaPierre WalletFlora MagnottiAngelina ProvostFanny MichalAmandine MartinFlaviana Di LorenzoBénédicte F. PyAntonio MolinaroThomas HenryNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brice Lagrange Sacha Benaoudia Pierre Wallet Flora Magnotti Angelina Provost Fanny Michal Amandine Martin Flaviana Di Lorenzo Bénédicte F. Py Antonio Molinaro Thomas Henry Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
description	Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct recognition of under-acylated lipid A.
format	article
author	Brice Lagrange Sacha Benaoudia Pierre Wallet Flora Magnotti Angelina Provost Fanny Michal Amandine Martin Flaviana Di Lorenzo Bénédicte F. Py Antonio Molinaro Thomas Henry
author_facet	Brice Lagrange Sacha Benaoudia Pierre Wallet Flora Magnotti Angelina Provost Fanny Michal Amandine Martin Flaviana Di Lorenzo Bénédicte F. Py Antonio Molinaro Thomas Henry
author_sort	Brice Lagrange
title	Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_short	Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_full	Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_fullStr	Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_full_unstemmed	Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
title_sort	human caspase-4 detects tetra-acylated lps and cytosolic francisella and functions differently from murine caspase-11
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/383b81a68c0640c08b987c32fdbd2fe2
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Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

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