Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

Purpose<b>:</b> The aim of this study is too correlate the sensitivity and thickness values of intraretinal layers at macula in healthy eyes and primary open-angle glaucoma (POAG) eyes. Methods<b>:</b> The thickness of different intraretinal segmentations was estimated by mea...

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Autores principales:	Jose Javier Garcia-Medina, Maurilia Rotolo, Elena Rubio-Velazquez, Maria Dolores Pinazo-Duran, Monica del-Rio-Vellosillo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microperimetry OCT glaucoma macula structure function Medicine R
Acceso en línea:	https://doaj.org/article/383f95c4f65544b2a9e790129cf124ac
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spelling	oai:doaj.org-article:383f95c4f65544b2a9e790129cf124ac2021-11-11T17:38:22ZMacular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT10.3390/jcm102150092077-0383https://doaj.org/article/383f95c4f65544b2a9e790129cf124ac2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5009https://doaj.org/toc/2077-0383Purpose<b>:</b> The aim of this study is too correlate the sensitivity and thickness values of intraretinal layers at macula in healthy eyes and primary open-angle glaucoma (POAG) eyes. Methods<b>:</b> The thickness of different intraretinal segmentations was estimated by means of optical coherence tomography (OCT) Spectralis (Heidelberg, Engineering, Inc., Heidelberg, Germany) with the posterior pole analysis program 8 × 8 in 91 eyes from 91 patients (60 with glaucoma and 31 healthy patients). Macular sensitivity was also measured with an MP-1 microperimeter (Nidek Instruments, Inc Padova, Italy) with a customized, 36-stimulus pattern adjusted to an anatomical correspondence with the OCT grid. Correlations were calculated by using Spearman’s rho and the results were represented in color maps. Results<b>:</b> Significant structure–function correlations were much more frequent in the glaucoma group than in control group. In general terms, associations were positive for inner retinal layers but negative correlations were also found for the inner nuclear layer and outer retinal layer in glaucoma. Conclusions: In general terms, significant structure–function correlations for different intraretinal layers are higher and wider in POAG eyes than in healthy eyes. Inner and outer retinal layers behave differently in terms of the structure–function relationship in POAG as assessed by microperimetry and OCT.Jose Javier Garcia-MedinaMaurilia RotoloElena Rubio-VelazquezMaria Dolores Pinazo-DuranMonica del-Rio-VellosilloMDPI AGarticlemicroperimetryOCTglaucomamaculastructurefunctionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5009, p 5009 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microperimetry OCT glaucoma macula structure function Medicine R
spellingShingle	microperimetry OCT glaucoma macula structure function Medicine R Jose Javier Garcia-Medina Maurilia Rotolo Elena Rubio-Velazquez Maria Dolores Pinazo-Duran Monica del-Rio-Vellosillo Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
description	Purpose<b>:</b> The aim of this study is too correlate the sensitivity and thickness values of intraretinal layers at macula in healthy eyes and primary open-angle glaucoma (POAG) eyes. Methods<b>:</b> The thickness of different intraretinal segmentations was estimated by means of optical coherence tomography (OCT) Spectralis (Heidelberg, Engineering, Inc., Heidelberg, Germany) with the posterior pole analysis program 8 × 8 in 91 eyes from 91 patients (60 with glaucoma and 31 healthy patients). Macular sensitivity was also measured with an MP-1 microperimeter (Nidek Instruments, Inc Padova, Italy) with a customized, 36-stimulus pattern adjusted to an anatomical correspondence with the OCT grid. Correlations were calculated by using Spearman’s rho and the results were represented in color maps. Results<b>:</b> Significant structure–function correlations were much more frequent in the glaucoma group than in control group. In general terms, associations were positive for inner retinal layers but negative correlations were also found for the inner nuclear layer and outer retinal layer in glaucoma. Conclusions: In general terms, significant structure–function correlations for different intraretinal layers are higher and wider in POAG eyes than in healthy eyes. Inner and outer retinal layers behave differently in terms of the structure–function relationship in POAG as assessed by microperimetry and OCT.
format	article
author	Jose Javier Garcia-Medina Maurilia Rotolo Elena Rubio-Velazquez Maria Dolores Pinazo-Duran Monica del-Rio-Vellosillo
author_facet	Jose Javier Garcia-Medina Maurilia Rotolo Elena Rubio-Velazquez Maria Dolores Pinazo-Duran Monica del-Rio-Vellosillo
author_sort	Jose Javier Garcia-Medina
title	Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
title_short	Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
title_full	Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
title_fullStr	Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
title_full_unstemmed	Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
title_sort	macular structure–function relationships of all retinal layers in primary open-angle glaucoma assessed by microperimetry and 8 × 8 posterior pole analysis of oct
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/383f95c4f65544b2a9e790129cf124ac
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Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

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