Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric in...

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Auteurs principaux:	Yvonne H. Chan, Sergey V. Venev, Konstantin B. Zeldovich, C. Robert Matthews
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e8
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spelling	oai:doaj.org-article:384072a0261e4a018bae7414c6c3b0e82021-12-02T14:42:33ZCorrelation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints10.1038/ncomms146142041-1723https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e82017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14614https://doaj.org/toc/2041-1723The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions.Yvonne H. ChanSergey V. VenevKonstantin B. ZeldovichC. Robert MatthewsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yvonne H. Chan Sergey V. Venev Konstantin B. Zeldovich C. Robert Matthews Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
description	The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions.
format	article
author	Yvonne H. Chan Sergey V. Venev Konstantin B. Zeldovich C. Robert Matthews
author_facet	Yvonne H. Chan Sergey V. Venev Konstantin B. Zeldovich C. Robert Matthews
author_sort	Yvonne H. Chan
title	Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_short	Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_full	Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_fullStr	Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_full_unstemmed	Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_sort	correlation of fitness landscapes from three orthologous tim barrels originates from sequence and structure constraints
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e8
work_keys_str_mv	AT yvonnehchan correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints AT sergeyvvenev correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints AT konstantinbzeldovich correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints AT crobertmatthews correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints
_version_	1718389622929620992

Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

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