Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric in...
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Nature Portfolio
2017
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oai:doaj.org-article:384072a0261e4a018bae7414c6c3b0e82021-12-02T14:42:33ZCorrelation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints10.1038/ncomms146142041-1723https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e82017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14614https://doaj.org/toc/2041-1723The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions.Yvonne H. ChanSergey V. VenevKonstantin B. ZeldovichC. Robert MatthewsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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Science Q Yvonne H. Chan Sergey V. Venev Konstantin B. Zeldovich C. Robert Matthews Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints |
description |
The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions. |
format |
article |
author |
Yvonne H. Chan Sergey V. Venev Konstantin B. Zeldovich C. Robert Matthews |
author_facet |
Yvonne H. Chan Sergey V. Venev Konstantin B. Zeldovich C. Robert Matthews |
author_sort |
Yvonne H. Chan |
title |
Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints |
title_short |
Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints |
title_full |
Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints |
title_fullStr |
Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints |
title_full_unstemmed |
Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints |
title_sort |
correlation of fitness landscapes from three orthologous tim barrels originates from sequence and structure constraints |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e8 |
work_keys_str_mv |
AT yvonnehchan correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints AT sergeyvvenev correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints AT konstantinbzeldovich correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints AT crobertmatthews correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints |
_version_ |
1718389622929620992 |