Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yvonne H. Chan, Sergey V. Venev, Konstantin B. Zeldovich, C. Robert Matthews
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:384072a0261e4a018bae7414c6c3b0e8
record_format dspace
spelling oai:doaj.org-article:384072a0261e4a018bae7414c6c3b0e82021-12-02T14:42:33ZCorrelation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints10.1038/ncomms146142041-1723https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e82017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14614https://doaj.org/toc/2041-1723The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions.Yvonne H. ChanSergey V. VenevKonstantin B. ZeldovichC. Robert MatthewsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yvonne H. Chan
Sergey V. Venev
Konstantin B. Zeldovich
C. Robert Matthews
Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
description The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions.
format article
author Yvonne H. Chan
Sergey V. Venev
Konstantin B. Zeldovich
C. Robert Matthews
author_facet Yvonne H. Chan
Sergey V. Venev
Konstantin B. Zeldovich
C. Robert Matthews
author_sort Yvonne H. Chan
title Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_short Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_full Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_fullStr Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_full_unstemmed Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
title_sort correlation of fitness landscapes from three orthologous tim barrels originates from sequence and structure constraints
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/384072a0261e4a018bae7414c6c3b0e8
work_keys_str_mv AT yvonnehchan correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints
AT sergeyvvenev correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints
AT konstantinbzeldovich correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints
AT crobertmatthews correlationoffitnesslandscapesfromthreeorthologoustimbarrelsoriginatesfromsequenceandstructureconstraints
_version_ 1718389622929620992