Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dend...

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Autores principales: Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O’Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3840bd9c9273487999b88e2c53427e0d
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spelling oai:doaj.org-article:3840bd9c9273487999b88e2c53427e0d2021-12-02T14:25:16ZHuman anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells10.1038/s41467-021-22375-x2041-1723https://doaj.org/article/3840bd9c9273487999b88e2c53427e0d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22375-xhttps://doaj.org/toc/2041-1723Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.Jake W. RhodesRachel A. BottingKirstie M. BertramErica E. VineHafsa RanaHeeva BaharlouPeter VeghThomas R. O’NeilAnneliese S. AshhurstJames FletcherGrant P. ParnellJ. Dinny GrahamNajla NasrJake J. K. LimLaith BarnoutiPeter HaertschMartijn P. GosselinkAngelina Di ReFaizur RezaGrahame CterctekoGregory J. JenkinsAndrew J. BrooksEllis PatrickScott N. ByrneEric HunterMuzlifah A. HaniffaAnthony L. CunninghamAndrew N. HarmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jake W. Rhodes
Rachel A. Botting
Kirstie M. Bertram
Erica E. Vine
Hafsa Rana
Heeva Baharlou
Peter Vegh
Thomas R. O’Neil
Anneliese S. Ashhurst
James Fletcher
Grant P. Parnell
J. Dinny Graham
Najla Nasr
Jake J. K. Lim
Laith Barnouti
Peter Haertsch
Martijn P. Gosselink
Angelina Di Re
Faizur Reza
Grahame Ctercteko
Gregory J. Jenkins
Andrew J. Brooks
Ellis Patrick
Scott N. Byrne
Eric Hunter
Muzlifah A. Haniffa
Anthony L. Cunningham
Andrew N. Harman
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
description Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.
format article
author Jake W. Rhodes
Rachel A. Botting
Kirstie M. Bertram
Erica E. Vine
Hafsa Rana
Heeva Baharlou
Peter Vegh
Thomas R. O’Neil
Anneliese S. Ashhurst
James Fletcher
Grant P. Parnell
J. Dinny Graham
Najla Nasr
Jake J. K. Lim
Laith Barnouti
Peter Haertsch
Martijn P. Gosselink
Angelina Di Re
Faizur Reza
Grahame Ctercteko
Gregory J. Jenkins
Andrew J. Brooks
Ellis Patrick
Scott N. Byrne
Eric Hunter
Muzlifah A. Haniffa
Anthony L. Cunningham
Andrew N. Harman
author_facet Jake W. Rhodes
Rachel A. Botting
Kirstie M. Bertram
Erica E. Vine
Hafsa Rana
Heeva Baharlou
Peter Vegh
Thomas R. O’Neil
Anneliese S. Ashhurst
James Fletcher
Grant P. Parnell
J. Dinny Graham
Najla Nasr
Jake J. K. Lim
Laith Barnouti
Peter Haertsch
Martijn P. Gosselink
Angelina Di Re
Faizur Reza
Grahame Ctercteko
Gregory J. Jenkins
Andrew J. Brooks
Ellis Patrick
Scott N. Byrne
Eric Hunter
Muzlifah A. Haniffa
Anthony L. Cunningham
Andrew N. Harman
author_sort Jake W. Rhodes
title Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
title_short Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
title_full Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
title_fullStr Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
title_full_unstemmed Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
title_sort human anogenital monocyte-derived dendritic cells and langerin+cdc2 are major hiv target cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3840bd9c9273487999b88e2c53427e0d
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