A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study

Objectives:. Previous studies demonstrated that extensive fluid loading and consequently positive fluid balances during sepsis resuscitation are associated with adverse outcome. Yet, the association between fluid balance and mortality after reversal of shock, that is, during deresuscitation, is larg...

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Autores principales: Niels van Mourik, MD, Bart F. Geerts, MD, PhD, MSc, MBA, Jan M. Binnekade, PhD, Denise P. Veelo, MD, PhD, Lieuwe D. J. Bos, , MD, PhD, MSc, W. Joost Wiersinga, MD, PhD, MBA, Tom van der Poll, MD, PhD, Olaf L. Cremer, MD, PhD, Marcus J. Schultz, MD, PhD, Alexander P. J. Vlaar, MD, PhD, MBA, on behalf of the MARS consortium, Laura R. A. Schouten, Lonneke A. van Vught, Maryse A. Wiewel, David S. Y. Ong, Jos F. Frencken, Marc Bonten, Peter M. C. Klein Klouwenberg, Roosmarijn T. M. van Hooijdonk, Mischa A. Huson, Marleen Straat, Esther Witteveen, Gerie J. Glas, Luuk Wieske, Brendon P. Scicluna, Hakima Belkasim-Bohoudi, Arie J. Hoogendijk
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Publicado: Wolters Kluwer 2020
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Acceso en línea:https://doaj.org/article/3843ab0805e14a35b4799141cd2ef11e
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spelling oai:doaj.org-article:3843ab0805e14a35b4799141cd2ef11e2021-11-25T07:52:32ZA Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study2639-802810.1097/CCE.0000000000000219https://doaj.org/article/3843ab0805e14a35b4799141cd2ef11e2020-10-01T00:00:00Zhttp://journals.lww.com/10.1097/CCE.0000000000000219https://doaj.org/toc/2639-8028Objectives:. Previous studies demonstrated that extensive fluid loading and consequently positive fluid balances during sepsis resuscitation are associated with adverse outcome. Yet, the association between fluid balance and mortality after reversal of shock, that is, during deresuscitation, is largely unappreciated. Our objective was to investigate the effects of fluid balance on mortality in the days after septic shock reversal. Design:. Retrospective observational cohort study. Setting:. ICUs of two university-affiliated hospitals in The Netherlands. Patients:. Adult patients admitted with septic shock followed by shock reversal. Reversal of septic shock was defined based on Sepsis-3 criteria as the first day that serum lactate was less than or equal to 2 mmol/L without vasopressor requirement. Interventions:. None. Measurements and Main Results:. Reversal of septic shock occurred in 636 patients, of whom 20% died in the ICU. Mixed-effects logistic regression modeling, adjusted for possible confounders, showed that fluid balance in the days after reversal of septic shock (until discharge or death) was an independent predictor of ICU mortality: odds ratio 3.18 (1.90–5.32) per 10 mL/kg increase in daily fluid balance. Similar results were found for 30-day, 90-day, hospital, and 1-year mortality: odds ratios 2.09 (1.64–2.67); 1.79 (1.38–2.32); 1.70 (1.40–2.07); and 1.53 (1.17–2.01), respectively. Positive cumulative fluid balances vs. neutral or negative fluid balances on the final day in the ICU were associated with increased ICU, hospital, 30-day, and 90-day mortality: odds ratios 3.46 (2.29–5.23); 3.39 (2.35–4.9); 5.33 (3.51–8.08); and 3.57 (2.49–5.12), respectively. Using restricted cubic splines, we found a dose-response relationship between cumulative fluid balance after shock reversal and ICU mortality. Conclusions:. A higher fluid balance in the days after septic shock reversal was associated with increased mortality. This stresses the importance of implementing restrictive and deresuscitative fluid management strategies after initial hemodynamic resuscitation. Prospective interventional studies are needed to confirm our results.Niels van Mourik, MDBart F. Geerts, MD, PhD, MSc, MBAJan M. Binnekade, PhDDenise P. Veelo, MD, PhDLieuwe D. J. Bos, , MD, PhD, MScW. Joost Wiersinga, MD, PhD, MBATom van der Poll, MD, PhDOlaf L. Cremer, MD, PhDMarcus J. Schultz, MD, PhDAlexander P. J. Vlaar, MD, PhD, MBAon behalf of the MARS consortiumLaura R. A. SchoutenLonneke A. van VughtMaryse A. WiewelDavid S. Y. OngJos F. FrenckenMarc BontenPeter M. C. Klein KlouwenbergRoosmarijn T. M. van HooijdonkMischa A. HusonMarleen StraatEsther WitteveenGerie J. GlasLuuk WieskeBrendon P. SciclunaHakima Belkasim-BohoudiArie J. HoogendijkWolters KluwerarticleMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care Explorations, Vol 2, Iss 10, p e0219 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
spellingShingle Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
Niels van Mourik, MD
Bart F. Geerts, MD, PhD, MSc, MBA
Jan M. Binnekade, PhD
Denise P. Veelo, MD, PhD
Lieuwe D. J. Bos, , MD, PhD, MSc
W. Joost Wiersinga, MD, PhD, MBA
Tom van der Poll, MD, PhD
Olaf L. Cremer, MD, PhD
Marcus J. Schultz, MD, PhD
Alexander P. J. Vlaar, MD, PhD, MBA
on behalf of the MARS consortium
Laura R. A. Schouten
Lonneke A. van Vught
Maryse A. Wiewel
David S. Y. Ong
Jos F. Frencken
Marc Bonten
Peter M. C. Klein Klouwenberg
Roosmarijn T. M. van Hooijdonk
Mischa A. Huson
Marleen Straat
Esther Witteveen
Gerie J. Glas
Luuk Wieske
Brendon P. Scicluna
Hakima Belkasim-Bohoudi
Arie J. Hoogendijk
A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study
description Objectives:. Previous studies demonstrated that extensive fluid loading and consequently positive fluid balances during sepsis resuscitation are associated with adverse outcome. Yet, the association between fluid balance and mortality after reversal of shock, that is, during deresuscitation, is largely unappreciated. Our objective was to investigate the effects of fluid balance on mortality in the days after septic shock reversal. Design:. Retrospective observational cohort study. Setting:. ICUs of two university-affiliated hospitals in The Netherlands. Patients:. Adult patients admitted with septic shock followed by shock reversal. Reversal of septic shock was defined based on Sepsis-3 criteria as the first day that serum lactate was less than or equal to 2 mmol/L without vasopressor requirement. Interventions:. None. Measurements and Main Results:. Reversal of septic shock occurred in 636 patients, of whom 20% died in the ICU. Mixed-effects logistic regression modeling, adjusted for possible confounders, showed that fluid balance in the days after reversal of septic shock (until discharge or death) was an independent predictor of ICU mortality: odds ratio 3.18 (1.90–5.32) per 10 mL/kg increase in daily fluid balance. Similar results were found for 30-day, 90-day, hospital, and 1-year mortality: odds ratios 2.09 (1.64–2.67); 1.79 (1.38–2.32); 1.70 (1.40–2.07); and 1.53 (1.17–2.01), respectively. Positive cumulative fluid balances vs. neutral or negative fluid balances on the final day in the ICU were associated with increased ICU, hospital, 30-day, and 90-day mortality: odds ratios 3.46 (2.29–5.23); 3.39 (2.35–4.9); 5.33 (3.51–8.08); and 3.57 (2.49–5.12), respectively. Using restricted cubic splines, we found a dose-response relationship between cumulative fluid balance after shock reversal and ICU mortality. Conclusions:. A higher fluid balance in the days after septic shock reversal was associated with increased mortality. This stresses the importance of implementing restrictive and deresuscitative fluid management strategies after initial hemodynamic resuscitation. Prospective interventional studies are needed to confirm our results.
format article
author Niels van Mourik, MD
Bart F. Geerts, MD, PhD, MSc, MBA
Jan M. Binnekade, PhD
Denise P. Veelo, MD, PhD
Lieuwe D. J. Bos, , MD, PhD, MSc
W. Joost Wiersinga, MD, PhD, MBA
Tom van der Poll, MD, PhD
Olaf L. Cremer, MD, PhD
Marcus J. Schultz, MD, PhD
Alexander P. J. Vlaar, MD, PhD, MBA
on behalf of the MARS consortium
Laura R. A. Schouten
Lonneke A. van Vught
Maryse A. Wiewel
David S. Y. Ong
Jos F. Frencken
Marc Bonten
Peter M. C. Klein Klouwenberg
Roosmarijn T. M. van Hooijdonk
Mischa A. Huson
Marleen Straat
Esther Witteveen
Gerie J. Glas
Luuk Wieske
Brendon P. Scicluna
Hakima Belkasim-Bohoudi
Arie J. Hoogendijk
author_facet Niels van Mourik, MD
Bart F. Geerts, MD, PhD, MSc, MBA
Jan M. Binnekade, PhD
Denise P. Veelo, MD, PhD
Lieuwe D. J. Bos, , MD, PhD, MSc
W. Joost Wiersinga, MD, PhD, MBA
Tom van der Poll, MD, PhD
Olaf L. Cremer, MD, PhD
Marcus J. Schultz, MD, PhD
Alexander P. J. Vlaar, MD, PhD, MBA
on behalf of the MARS consortium
Laura R. A. Schouten
Lonneke A. van Vught
Maryse A. Wiewel
David S. Y. Ong
Jos F. Frencken
Marc Bonten
Peter M. C. Klein Klouwenberg
Roosmarijn T. M. van Hooijdonk
Mischa A. Huson
Marleen Straat
Esther Witteveen
Gerie J. Glas
Luuk Wieske
Brendon P. Scicluna
Hakima Belkasim-Bohoudi
Arie J. Hoogendijk
author_sort Niels van Mourik, MD
title A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study
title_short A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study
title_full A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study
title_fullStr A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study
title_full_unstemmed A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study
title_sort higher fluid balance in the days after septic shock reversal is associated with increased mortality: an observational cohort study
publisher Wolters Kluwer
publishDate 2020
url https://doaj.org/article/3843ab0805e14a35b4799141cd2ef11e
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