TRIM59: A potential diagnostic and prognostic biomarker in human tumors.

TRIM59 is a protein that is highly expressed in a variety of tumors and promotes tumor development. However, the use of TRIM59 as tumor diagnosis and prognosis biomarker has not been fully explored. We collected datasets from the cancer genome atlas (TCGA) and gene expression omnibus (GEO) to invest...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zheng Jin, Liping Liu, Youran Yu, Dong Li, Xun Zhu, Dongmei Yan, Zhenhua Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3845bf7fa3b64b478b0be081db19dc2d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3845bf7fa3b64b478b0be081db19dc2d
record_format	dspace
spelling	oai:doaj.org-article:3845bf7fa3b64b478b0be081db19dc2d2021-12-02T20:14:32ZTRIM59: A potential diagnostic and prognostic biomarker in human tumors.1932-620310.1371/journal.pone.0257445https://doaj.org/article/3845bf7fa3b64b478b0be081db19dc2d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257445https://doaj.org/toc/1932-6203TRIM59 is a protein that is highly expressed in a variety of tumors and promotes tumor development. However, the use of TRIM59 as tumor diagnosis and prognosis biomarker has not been fully explored. We collected datasets from the cancer genome atlas (TCGA) and gene expression omnibus (GEO) to investigate its potential as a biomarker for diagnosis and prognosis. A total of 46 studies, including 11,558 patients were included in this study. Here, we showed that TRIM59 was significantly upregulated in 15 type of human solid tumors in comparison to their adjacent tissues. Receiver operating characteristic curve (ROC) results provided further evidence for the use of TRIM59 as a potential tumor diagnosis biomarker. Overall survival (OS) was compared between TRIM59 high expression and low expression groups. High expression of TRIM59 indicated a poor prognosis in multiple solid tumors. Taken together, these analyses showed that TRIM59 was upregulated in various types of tumors and had the potential to be used as a diagnostic and prognostic biomarker in human solid tumors.Zheng JinLiping LiuYouran YuDong LiXun ZhuDongmei YanZhenhua ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257445 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng Jin Liping Liu Youran Yu Dong Li Xun Zhu Dongmei Yan Zhenhua Zhu TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
description	TRIM59 is a protein that is highly expressed in a variety of tumors and promotes tumor development. However, the use of TRIM59 as tumor diagnosis and prognosis biomarker has not been fully explored. We collected datasets from the cancer genome atlas (TCGA) and gene expression omnibus (GEO) to investigate its potential as a biomarker for diagnosis and prognosis. A total of 46 studies, including 11,558 patients were included in this study. Here, we showed that TRIM59 was significantly upregulated in 15 type of human solid tumors in comparison to their adjacent tissues. Receiver operating characteristic curve (ROC) results provided further evidence for the use of TRIM59 as a potential tumor diagnosis biomarker. Overall survival (OS) was compared between TRIM59 high expression and low expression groups. High expression of TRIM59 indicated a poor prognosis in multiple solid tumors. Taken together, these analyses showed that TRIM59 was upregulated in various types of tumors and had the potential to be used as a diagnostic and prognostic biomarker in human solid tumors.
format	article
author	Zheng Jin Liping Liu Youran Yu Dong Li Xun Zhu Dongmei Yan Zhenhua Zhu
author_facet	Zheng Jin Liping Liu Youran Yu Dong Li Xun Zhu Dongmei Yan Zhenhua Zhu
author_sort	Zheng Jin
title	TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
title_short	TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
title_full	TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
title_fullStr	TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
title_full_unstemmed	TRIM59: A potential diagnostic and prognostic biomarker in human tumors.
title_sort	trim59: a potential diagnostic and prognostic biomarker in human tumors.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3845bf7fa3b64b478b0be081db19dc2d
work_keys_str_mv	AT zhengjin trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors AT lipingliu trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors AT youranyu trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors AT dongli trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors AT xunzhu trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors AT dongmeiyan trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors AT zhenhuazhu trim59apotentialdiagnosticandprognosticbiomarkerinhumantumors
_version_	1718374637830668288

TRIM59: A potential diagnostic and prognostic biomarker in human tumors.

Ejemplares similares